Objective To study the relationship between lung cancer clinicopathological features and MALAT-1 lncRNA expression in human lung cancer tissues.Methods The MALAT-1 expression levels in the cancerous and normal tissues of 76 lung cancer patients were measured by real-time quantitative PCR (RT-qPCR).Results The expression levels of MALAT-1 gene were down-regulated in 58％ (44/76) primary lung cancer patients,compared with the matched normal tissues.The difference of MALAT-1 expression level between cancerous tissues and the matched normal tissues was significant (t =-7.648,P ＜0.001).Furthermore,The expression levels of MALAT-1 had difference among cell differentiation,tumor metastasis,tumor pathological classification and smoking (P ＜ 0.05).The survival time of the group which had ＜ 50％ decreased MALAT-1 expression level was significantly longer than that whose MALAT-1 expression level were reduced ≥50％.Cox multivariate regression analysis showed that cell differentiation,tumor metastasis,tumor pathological classification amd expression of MALAT-1 were an independent prognostic factor for NSCLC.Conclusions The expression of MALAT-1 might play an important role in non-small lung cancer and thus maybe a biomarker for lung cancer in screening,diagnosis and prognosis.
NETL
NSTL
维普
万方数据
