血清降钙素原在NICU的临床应用分析
Clinical application analysis of serum procalcitonin in NICU
李凯 1刘超 1王娟1
作者信息
- 1. 463000 河南省驻马店市第一人民医院新生儿科
- 折叠
摘要
目的 探讨血清降钙素原检测在新生儿重症监护病房的应用价值.方法 将178例危重晚期新生儿分为三组:细菌感染组68例,病毒感染组56例,非感染组54例.回顾性分析危重晚期新生儿血清降钙素原(PCT)水平,比较PCT检测阴性的非细菌感染危重晚期新生儿不用抗生素治疗与经验性使用抗生素治疗的疗效差异.结果 细菌感染组、病毒感染组和非感染组PCT阳性率分别为73.5％、12.5％和13.0％,细菌感染组和病毒感染组、非感染组差异有统计学意义(P＜0.01).PCT检测阴性的非细菌感染危重晚期新生儿不用抗生素治疗与经验性使用抗生素治疗的疗效差异无统计学意义(P＞0.05).结论 在NICU病房,血清PCT可用作晚期新生儿细菌感染与病毒等感染的鉴别诊断指标,指导临床抗生素的合理应用,降低抗生素使用率,减少多重耐药菌的产生.
Abstract
Objective To investigate the application value of serum procalcitonin (PCT) detection on neonatal intensive care unit(NICU).Methods The 178 cases of critical newborns in our NICU were divided into three groups:the bacterial infection group(n =68),viral infection group(n =56)and non-infection group(n =54).The serum PCT levels were retrospectively analyzed.The effects of non-antibiotic therapy and empirical use of antibiotics on PCT-negative bacterial infections in critically ill late neonatal were compared.Results In bacterial infection group,viral infection group and non-infection group,the positive rates of PCT were 73.5％,12.5％ and 13.0％.Compared with viral infection group and non-infection group,the positive rate of PCT in bacterial infection group was significantly different (P ＜ 0.01).There were no significant differences in the effects of non-antibiotic therapy and empirical use of antibiotics on PCT-negative bacterial infections in critically ill late neonate (P ＞ 0.05).Conclusions Serum PCT may be used as differential diagnosis indicators of bacterial infection and virus infection in the NICU,and can guide clinical rational use of antibiotics,reduce the use of antibiotics and the multiple resistant bacteria.
关键词
降钙素原/新生儿重症监护病房/感染/抗生素Key words
Procalcitonin/Neonatal intensive care unit/Infection/Antibiotics引用本文复制引用
出版年
2014
NETL
NSTL
维普
万方数据