摘要
目的 观察和分析贫血及低蛋白血症对慢性心力衰竭(CHF)患者预后的影响.方法 选取117例首诊CHF患者作为研究对象,于入院时对其血红蛋白(Hb)、血白蛋白(Alb)、前白蛋白(PA)、铁蛋白(Fer)、总铁结合力(TIBC)进行检测和记录,根据患者出院1年后的生存情况将其分为存活组和死亡组,对两组患者的上述观察指标进行比较,并分析患者发生死亡与上述指标的关系.结果 出院后1年,纳入患者中有87例存活,占74.4％,有30例患者死亡,占25.6％,其中,存活组的男性患者比例显著低于死亡组(P＜0.05),存活组的年龄显著小于死亡组(P＜0.05);存活组患者的Hb、Alb、PA水平显著高于死亡组(P＜0.05),两组在Fer、TIBC水平方面比较差异无统计学意义(P＞0.05);多元回归结果显示,患者Hb、Alb、PA水平与患者发生死亡呈负相关(P＜0.05,OR值分别为0.617、0.964、0.528),而患者年龄和性别为男性与患者发生死亡呈正相关(P＜0.05,OR值分别为1.738、1.317).结论 CHF患者出院后1年病死率较高,Hb、Alb、PA水平是CHF患者发生死亡的保护因素,而年龄和性别为男性则是CHF患者发生死亡的危险因素,临床医生应根据相关因素制定相应的治疗方案.
Abstract
Objective To observe and analyze the effects of anemia and hypoproteinemia on prognosis of patients with chronic heart failure (CHF).Methods One hundred and seventeen CHF patients were selected as the research objects.On the admission day,the hemoglobin (Hb),serum albumin (Alb),prealbumin (PA),serum ferritin (Fer),total iron binding capacity (TIBC) levels of the patients were detected and recorded.The patients were divided into the survival group and the death group according to their survival situation at 1 year after discharged day.The indexes of the patients in the two groups were compared and observed and the relationship between the indexes and the death of the patients were analyzed.Results One year after discharged day,87 patients enrolled survived,accounting for 74.4％,30 patients died,accounting for 25.6％.Among them,the proportion of male patients in the survival group was significantly lower than that in the death group (P ＜ 0.05).The age of the patients in the survival group was significantly less than that in the death group (P ＜ 0.05) ; the Hb,Alb,PA levels of the patients in the survival group were significantly higher than those in the death group (P ＜ 0.05),and the differences in Fer,TIBC levels between the two groups were not significant (P ＞ 0.05); multiple regression showed that the death was negatively correlated with Hb,Alb,PA levels of the patients (P ＜ 0.05,OR =0.617,0.964,0.528),and the patient' s age and male were positively correlated with the death of the patients (P ＜0.05,OR =1.738,1.317).Conclusions The mortality of CHF patients at 1 year after discharge is high.The Hb,Alb,PA levels were protective factors from death of patients with CHF,while age and male are the risk factors in death of patients with CHF.The clinicians should make the corresponding treatment plan according to the related factors.
NETL
NSTL
维普
万方数据