尿微量白蛋白水平与2型糖尿病患者视网膜病变的相关性研究
Correlation of urinary albumin levels with the severity of retinopathy in patients with type 2 diabetes
李小萍 1程福元 1吕敏1
作者信息
- 1. 046200 山西省长治市潞安集团总医院内分泌科
- 折叠
摘要
目的 探讨2型糖尿病患者尿白蛋白排泄率(UAER)水平与糖尿病视网膜病变(DR)的关系.方法 选择221例2型糖尿病患者,并依据眼底检测结果将其分为无DR组(NDR)、非增殖期DR组(NPDR)及增殖期DR组(PDR),对各组临床生化指标进行观察并统计,分析DR病变的危险因素.结果 DR组患病率为39.36％,NPDR组与PDR组分别为35.29％、4.07％.NPDR组与PDR组患者糖尿病病程、糖化血红蛋白(HbA1c)等指标均高于NDR组(P＜0.05).PDR组收缩压(SBP)、总胆固醇等指标均高于NDR组(P＜0.05),血肌酐、尿微量白蛋白也高于NDR组及NPDR组(P＜0.05);NDR及NPDR组肾小球滤过率高于PDR组(P＜0.05).UAER与DR发生率之间存在一定正相关关系(P＜0.05).回归结果表明糖尿病病程、HbA1c、UAER等都是影响DR的独立危险因素.结论 UAER与DR之间存在密切的关系,可以通过筛查来尽早检出DR.
Abstract
Objective To investigate the correlation of urinary albumin excretion rate (UAER)with diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (DM).Methods Two hundred and twenty-one patients with type 2 diabetes mellitus were selected and divided into non DR group (NDR),non proliferative DR (NPDR) group and prohf~ative DR group (PDR) according to fundus examination results.The clinical biochemical indexes and risk factors of DR lesions were observed and analyzed.Results The prevalence rate of DR group was 39.36％,and was 35.29％,4.07％ of NPDR group and PDR group,respectively.The indexes of diabetes,glycosylated hemoglobin (HbAlc) and other indicators of NPDR and PDR group were higher than those of NDR group (P ＜ 0.05).In PDR group,the systolic blood pressure (SBP),total cholesterol and other indicators were higher than those in NDR group;the levels of serum creatinine (Cr),urine albumin was also higher than those in NDR and NPDR group (P ＜0.05);The glomerular filtration rate of NDR and NPDR group was higher than that of PDR group (P ＜ 0.05).There was positive correlation of the incidence of UAER with DR (P ＜ 0,05).Regression results showed that the duration of diabetes,HbAlc,UAER were the independent risk factors of DR.Conclusions There is close relationship between UAER and DR,which can be detected as early as possible by screening DR.
关键词
2型糖尿病/尿白蛋白排泄率/视网膜病变/相关性Key words
Type 2 diabetes mellitus/Urinary albumin excretion rate/Retinopathy/Correlation引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据