Application effect of dexmedetomidine nasal drops for sedation in pediatric cardiac ultrasound examination
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目的 探讨右美托咪定滴鼻镇静在小儿心脏彩超检查中的应用效果。 方法 随机对照研究。抽取2021年3月至2023年3月于郑州大学第一附属医院小儿内科住院并行心脏彩超检查的患儿400例，按随机数字表法分为对照组和研究组，每组200例。对照组患儿心脏彩超检查前30 min给予肌肉注射苯巴比妥钠3 mg/kg进行镇静，研究组患儿心脏彩超检查前5 min给予鼻腔内滴注右美托咪定2.5 μg/kg进行镇静。比较两组患儿的基线资料、镇静效果、给药抵抗性评分、彩超检查抵抗性评分及不良反应发生情况。 结果 研究组镇静起效时间、苏醒时间、总镇静时间均短于对照组，差异有统计学意义(P<0.05)；研究组患儿给予镇静药及彩超检查操作时的抵抗性评分均低于对照组，差异有统计学意义(P<0.05)；两组患儿Ramsay镇静评分比较差异未见统计学意义(P>0.05)；研究组用药相关不良反应发生率(6.00%，12/200)与对照组(7.00%，14/200)比较，差异未见统计学意义(P>0.05)。 结论 右美托咪定滴鼻在小儿心脏彩超检查中镇静效果显著且安全，具有镇静起效快、检查结束后苏醒快、给药及检查抵抗反应小等优势。 Objective To investigate the application effect of dexmedetomidine nasal drops for sedation in pediatric cardiac ultrasound examination. Methods This study was a randomized controlled trial. A total of 400 children who were hospitalized in the Department of Pediatrics of the First Affiliated Hospital of Zhengzhou University and underwent cardiac color Doppler ultrasound examination from March 2021 to March 2023 were selected. And they were divided into a control group and a study group by random number table method, with 200 cases in each group. The control group was given intramuscular injection of 3 mg/kg phenobarbital sodium for sedation at 30 minutes before cardiac ultrasound examination. The study group was given dexmedetomidine nasal drops of 2.5 μg/kg for sedation at 5 minutes before the cardiac ultrasound examination. The baseline data, sedative effect, drug resistance score, color Doppler ultrasound resistance score, and adverse reactions were compared between the two groups. Results The onset time, awakening time, and total sedation time of the study group were all shorter than those of the control group (P<0.05). The resistance scores of children in the study group during sedative medication and ultrasound examination were lower than those in the control group (P<0.05). There was no statistically significant difference in Ramsay sedation scores between the two groups (P>0.05). There was no significant difference in the incidence of drug-related adverse reactions between the study group (6.00%, 12/200) and the control group (7.00%, 14/200),P>0.05. Conclusions Dexmedetomidine nasal drops has a significant sedative effect and safety in pediatric cardiac color Doppler ultrasound. It has the advantages of rapid onset of sedation, rapid recovery after the examination, and small resistance to administration and examination.
Objective To investigate the application effect of dexmedetomidine nasal drops for sedation in pediatric cardiac ultrasound examination. Methods This study was a randomized controlled trial. A total of 400 children who were hospitalized in the Department of Pediatrics of the First Affiliated Hospital of Zhengzhou University and underwent cardiac color Doppler ultrasound examination from March 2021 to March 2023 were selected. And they were divided into a control group and a study group by random number table method, with 200 cases in each group. The control group was given intramuscular injection of 3 mg/kg phenobarbital sodium for sedation at 30 minutes before cardiac ultrasound examination. The study group was given dexmedetomidine nasal drops of 2.5 μg/kg for sedation at 5 minutes before the cardiac ultrasound examination. The baseline data, sedative effect, drug resistance score, color Doppler ultrasound resistance score, and adverse reactions were compared between the two groups. Results The onset time, awakening time, and total sedation time of the study group were all shorter than those of the control group (P<0.05). The resistance scores of children in the study group during sedative medication and ultrasound examination were lower than those in the control group (P<0.05). There was no statistically significant difference in Ramsay sedation scores between the two groups (P>0.05). There was no significant difference in the incidence of drug-related adverse reactions between the study group (6.00%, 12/200) and the control group (7.00%, 14/200),P>0.05. Conclusions Dexmedetomidine nasal drops has a significant sedative effect and safety in pediatric cardiac color Doppler ultrasound. It has the advantages of rapid onset of sedation, rapid recovery after the examination, and small resistance to administration and examination.
DexmedetomidineCardiac color Doppler ultrasoundNasal dropsSedative effect
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