Research progress on the mechanism of GPER in endometrial cancer
戚梦 1金玉茜 1司露露 1刘亚娜 1郭瑞霞 1常青
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作者信息
1. 郑州大学第一附属医院妇科，郑州 450052
折叠
摘要
雌激素是人体中一种重要的类固醇激素，可通过多种雌激素受体介导的基因组和快速非基因组途径诱导多效性细胞反应。其中，快速非基因组途径主要由G蛋白偶联雌激素受体(GPER)通过蛋白激酶途径和第二信使介导。目前越来越多证据表明GPER通过激活多种信号通路参与子宫内膜癌的发生发展。因此，从GPER的角度探讨雌激素促进子宫内膜癌进展的作用机制，将为子宫内膜癌的防治提供新的思路。 Estrogen is an important steroid hormone in the human body, it can induce pluripotent cellular responses through various estrogen receptor mediated genomic and rapid non-genomic pathways. Among them, the rapid non-genomic pathway is mainly mediated by the G protein-coupled estrogen receptor (GPER) through the protein kinase pathway and the second messenger pathway. Currently, increasing evidence suggests that GPER is involved in the occurrence and development of endometrial cancer by activating multiple signaling pathways. Therefore, investigating the mechanism of estrogen promoting the progression of endometrial cancer from the perspective of GPER will provide new ideas for the prevention and treatment of endometrial cancer.
Abstract
Estrogen is an important steroid hormone in the human body, it can induce pluripotent cellular responses through various estrogen receptor mediated genomic and rapid non-genomic pathways. Among them, the rapid non-genomic pathway is mainly mediated by the G protein-coupled estrogen receptor (GPER) through the protein kinase pathway and the second messenger pathway. Currently, increasing evidence suggests that GPER is involved in the occurrence and development of endometrial cancer by activating multiple signaling pathways. Therefore, investigating the mechanism of estrogen promoting the progression of endometrial cancer from the perspective of GPER will provide new ideas for the prevention and treatment of endometrial cancer.
关键词
雌激素/G蛋白偶联雌激素受体/子宫内膜癌
Key words
Estrogens/G protein-coupled estrogen receptor/Endometrial cancer
万方数据