Correlation between axillary lymph node metastasis and clinical features of breast cancer
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目的 分析乳腺癌腋窝淋巴结转移与临床特征的相关性。 方法 观察性研究。抽取2022年7月至2023年3月郑州大学第一附属医院收治的乳腺癌患者184例，依据乳腺癌腋窝淋巴结转移情况分为腋窝淋巴结转移组(59例)和无腋窝淋巴结转移组(125例)。比较两组的临床特征，包括肿块最大直径、肿块位置、是否有脉管瘤栓及雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体-2(HER-2)、Ki-67抗原(Ki-67)的表达，分析乳腺癌腋窝淋巴结转移与临床特征的相关性。 结果 腋窝淋巴结转移组Ki-67阳性表达率、脉管瘤栓率高于无腋窝淋巴结转移组，差异有统计学意义(P<0.05)；两组肿块最大直径、肿块位置及ER、PR、HER-2表达比较，差异未见统计学意义(P>0.05)。Logistic回归分析结果显示，Ki-67阳性表达、脉管瘤栓可能是乳腺癌腋窝淋巴结转移的影响因素(OR＝3.26、12.67，P均<0.05)。 结论 乳腺癌腋窝淋巴结转移与肿块最大直径、肿块位置及ER、PR、HER-2的表达无关，与Ki-67阳性表达、脉管瘤栓有关。 Objective To analyze the correlation between axillary lymph node metastasis and clinical features of breast cancer. Methods This stidy was an observational study. A total of 184 breast cancer patients admitted to the First Affiliated Hospital of Zhengzhou University from July 2022 to March 2023 were selected, and they were divided into axillary lymph node metastasis group (59 cases) and non-axillary lymph node metastasis group (125 cases) according to the occurrence of axillary lymph node metastasis from breast cancer. The clinical features, including the major diameter of the mass, location of the mass, vasculoma thrombosis and expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2), Ki-67 antigen (Ki-67), of the two groups were compared. The correlation between axillary lymph node metastasis and clinical features of breast cancer was analyzed. Results The positive expression rate of Ki-67 and incidence of vasculoma thrombosis of the axillary lymph node metastasis group were higher than those of the non-axillary lymph node metastasis group, and the differences were statistically significant (P<0.05). There was no significant difference in the the major diameter of the mass, location of the mass and expression of ER, PR or HER-2 between the two groups (P>0.05). The results of logistic regression analysis showed that positive expression of Ki-67 and vasculoma thrombosis could be the influencing factors of axillary lymph node metastasis from breast cancer (OR=3.26, 12.67 all P<0.05). Conclusions Axillary lymph node metastasis from breast cancer is not related to the major diameter of the mass, location of the mass and the expression of ER, PR or HER-2 however, it is related to the positive expression of Ki-67 and vasculoma thrombosis.
Objective To analyze the correlation between axillary lymph node metastasis and clinical features of breast cancer. Methods This stidy was an observational study. A total of 184 breast cancer patients admitted to the First Affiliated Hospital of Zhengzhou University from July 2022 to March 2023 were selected, and they were divided into axillary lymph node metastasis group (59 cases) and non-axillary lymph node metastasis group (125 cases) according to the occurrence of axillary lymph node metastasis from breast cancer. The clinical features, including the major diameter of the mass, location of the mass, vasculoma thrombosis and expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2), Ki-67 antigen (Ki-67), of the two groups were compared. The correlation between axillary lymph node metastasis and clinical features of breast cancer was analyzed. Results The positive expression rate of Ki-67 and incidence of vasculoma thrombosis of the axillary lymph node metastasis group were higher than those of the non-axillary lymph node metastasis group, and the differences were statistically significant (P<0.05). There was no significant difference in the the major diameter of the mass, location of the mass and expression of ER, PR or HER-2 between the two groups (P>0.05). The results of logistic regression analysis showed that positive expression of Ki-67 and vasculoma thrombosis could be the influencing factors of axillary lymph node metastasis from breast cancer (OR=3.26, 12.67 all P<0.05). Conclusions Axillary lymph node metastasis from breast cancer is not related to the major diameter of the mass, location of the mass and the expression of ER, PR or HER-2 however, it is related to the positive expression of Ki-67 and vasculoma thrombosis.
Breast neoplasmsAxillary lymph node metastasisMajor diameterLocation
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