Influencing factors of occurrence of male primary renal calculus in Central Plains
李中学 1马艳丽
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作者信息
1. 郑州市第七人民医院泌尿外科，郑州 450000
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摘要
目的 分析中原地区男性原发性肾结石发生的影响因素。 方法 纳入2022年3月至2023年3月于郑州市第七人民医院进行健康体检的男性172例，检测外周血维生素D受体基因FokI多态性，依据肾结石发生情况将其分为发生组(30例)和未发生组(142例)。分析两组FokI多态性基因分布及一般资料，采用多因素Logistic回归分析中原地区男性原发性肾结石发生的影响因素。 结果 发生组ff基因型占比高于未发生组，差异有统计学意义(P<0.05)。发生组体质指数、每日饮水量、饮食习惯、肾结石家族史构成比与未发生组比较，差异有统计学意义(P<0.05)。两组年龄、文化程度、饮酒史、吸烟史、饮用水类型构成比较，差异未见统计学意义(P>0.05)。多因素Logistic回归结果显示，FokⅠ基因型、体质指数、每日饮水量、饮食习惯、有肾结石家族史是男性原发性肾结石发生的独立影响因素(OR＝2.11、1.91、0.40、5.87、8.76, P均<0.05)。 结论 FokⅠ基因型、体质量、每日饮水量、饮食习惯、有肾结石家族史是中原地区男性原发性肾结石发生的独立影响因素，该地区男性应适当增加每日饮水量、控制蛋白质摄入量，ff基因型者、有肾结石家族史者应注意调整饮食结构及生活方式。 Objective To analyze the influencing factors of occurrence of male primary renal calculus in Central Plains. Methods A total of 172 males who underwent physical examination in the Seventh People’s Hospital of Zhengzhou from March 2022 to March 2023 were enrolled in the study, and they underwent test for vitamin D receptor gene FokI polymorphism in peripheral blood. According to incidence of renal calculus, they were divided into occurrence group (30 cases) and non-occurrence group (142 cases). The distribution of FokI polymorphisms and general data in the two groups were analyzed. The univariate and multivariate logistic regression analyses were used to analyze the influencing factors of occurrence of primary renal calculu in males in the Central Plains. Results The proportion of ff genotype in the occurrence group was higher than that in the non-occurrence group, and the difference was statistically significant (P<0.05). There were significant differences in body mass index, daily water intake, dietary eating habits, and family history of renal calculu between the occurrence group and the non-occurrence group (P<0.05). There was no significant difference in the proportions of age, education level, drinking history, smoking history and drinking water type between the two groups (P>0.05). The results of multivariate logistic regression analysis showed that FokI genotype, body mass index, daily water intake, dietary eating habits, and family history of renal calculu were independent influencing factors for the occurrence of primary kidney stones in males (OR=2.11, 1.91, 0.40, 5.87, 8.76 all P<0.05). Conclusions FokI genotype, body weight, daily water intake, dietary eating habits, and family history of renal calculu are independent influencing factors for the occurrence of male primary kidney stones in Central Plains. Men in Central Plains should appropriately increase their daily water intake and control protein intake. Men with ff genotype and family history of renal calculu should pay attention to adjusting their diet and lifestyle.
Abstract
Objective To analyze the influencing factors of occurrence of male primary renal calculus in Central Plains. Methods A total of 172 males who underwent physical examination in the Seventh People’s Hospital of Zhengzhou from March 2022 to March 2023 were enrolled in the study, and they underwent test for vitamin D receptor gene FokI polymorphism in peripheral blood. According to incidence of renal calculus, they were divided into occurrence group (30 cases) and non-occurrence group (142 cases). The distribution of FokI polymorphisms and general data in the two groups were analyzed. The univariate and multivariate logistic regression analyses were used to analyze the influencing factors of occurrence of primary renal calculu in males in the Central Plains. Results The proportion of ff genotype in the occurrence group was higher than that in the non-occurrence group, and the difference was statistically significant (P<0.05). There were significant differences in body mass index, daily water intake, dietary eating habits, and family history of renal calculu between the occurrence group and the non-occurrence group (P<0.05). There was no significant difference in the proportions of age, education level, drinking history, smoking history and drinking water type between the two groups (P>0.05). The results of multivariate logistic regression analysis showed that FokI genotype, body mass index, daily water intake, dietary eating habits, and family history of renal calculu were independent influencing factors for the occurrence of primary kidney stones in males (OR=2.11, 1.91, 0.40, 5.87, 8.76 all P<0.05). Conclusions FokI genotype, body weight, daily water intake, dietary eating habits, and family history of renal calculu are independent influencing factors for the occurrence of male primary kidney stones in Central Plains. Men in Central Plains should appropriately increase their daily water intake and control protein intake. Men with ff genotype and family history of renal calculu should pay attention to adjusting their diet and lifestyle.
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