Effect of levonorgestrel intrauterine system in preventing recurrence of endometrial polyps after hysteroscopic transcervical resection of polyp
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目的 分析宫腔镜子宫内膜息肉电切术(TCRP)后应用左炔诺孕酮宫内节育系统(LNG-IUS)预防子宫内膜息肉(EP)复发的效果。 方法 回顾性抽取2019年3月至2022年3月信阳市妇幼保健院收治的EP患者78例，依据治疗方案分为对照组(39例)和观察组(39例)。两组均予以TCRP治疗，对照组术后口服地屈孕酮，观察组术后予以LNG-IUS。比较两组临床效果、月经恢复情况(月经经期、月经周期、月经量)、血红蛋白(Hb)水平、子宫内膜厚度、不良反应及EP复发情况。 结果 观察组总有效率(94.87%，37/39)高于对照组(76.92%，30/39)，P<0.05。术后12个月，两组月经经期、月经周期比较差异未见统计学意义(P>0.05)，观察组月经量少于对照组(P<0.05)。术后3、6、12个月，观察组Hb水平高于对照组(P<0.05)，观察组子宫内膜厚度小于对照组(P<0.05)。两组不良反应发生率比较差异未见统计学意义(P>0.05)；观察组EP复发率(2.56%，1/39)低于对照组(20.51%，8/39)，P<0.05。 结论 TCRP后应用LNG-IUS治疗可提高临床效果，减小子宫内膜厚度，改善月经情况，降低EP复发率。 Objective To analyze the effect of levonorgestrel-releasing intrauterine system (LNG-IUS) in preventing recurrence of endometrial polyps (EP) after hysteroscopic transcervical resection of polyp (TCRP). Methods A total of 78 EP patients admitted to Xinyang Maternal and Child Care Hospital from March 2019 to March 2022 were selected retrospectively, and the patients were divided into control group (39 cases) and observation group (39 cases) according to the treatment plan. Both groups were treated by TCRP. The control group was treated with oral dydrogesterone after operation, and the observation group was treated by LNG-IUS after operation. The clinical effect, menstrual recovery evaluated by menstrual period, menstrual cycle and menstrual volume, level of hemoglobin (Hb), endometrial thickness, incidence of adverse reactions and recurrence of EP were compared between the two groups. Results The total effective rate of the observation group (94.87%, 37/39) was higher than that of the control group (76.92%, 30/39), P<0.05. There was no significant difference in menstrual period and menstrual cycle between the two groups 12 months after surgery (P>0.05). The menstrual volume in the observation group was lower than that in the control group 12 months after surgery (P<0.05). Compared with the control group, the observation group had higher level of Hb and thicker endometrial thickness 3, 6 and 12 months after surgery (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). The recurrence rate of EP in the observation group (2.56%, 1/39) was lower than that in the control group (20.51%, 8/39),P<0.05. Conclusions The application of LNG-IUS treatment after TCRP can improve the clinical effect, reduce the endometrial thickness, improve the menstrual condition, and reduce the recurrence rate of EP.
Objective To analyze the effect of levonorgestrel-releasing intrauterine system (LNG-IUS) in preventing recurrence of endometrial polyps (EP) after hysteroscopic transcervical resection of polyp (TCRP). Methods A total of 78 EP patients admitted to Xinyang Maternal and Child Care Hospital from March 2019 to March 2022 were selected retrospectively, and the patients were divided into control group (39 cases) and observation group (39 cases) according to the treatment plan. Both groups were treated by TCRP. The control group was treated with oral dydrogesterone after operation, and the observation group was treated by LNG-IUS after operation. The clinical effect, menstrual recovery evaluated by menstrual period, menstrual cycle and menstrual volume, level of hemoglobin (Hb), endometrial thickness, incidence of adverse reactions and recurrence of EP were compared between the two groups. Results The total effective rate of the observation group (94.87%, 37/39) was higher than that of the control group (76.92%, 30/39), P<0.05. There was no significant difference in menstrual period and menstrual cycle between the two groups 12 months after surgery (P>0.05). The menstrual volume in the observation group was lower than that in the control group 12 months after surgery (P<0.05). Compared with the control group, the observation group had higher level of Hb and thicker endometrial thickness 3, 6 and 12 months after surgery (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). The recurrence rate of EP in the observation group (2.56%, 1/39) was lower than that in the control group (20.51%, 8/39),P<0.05. Conclusions The application of LNG-IUS treatment after TCRP can improve the clinical effect, reduce the endometrial thickness, improve the menstrual condition, and reduce the recurrence rate of EP.
Endometrial polypsHysteroscopic transcervical resection of polypLevonorgestrel-releasing intrauterine system
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