Value of serum PCT and FIB in predicting the risk of toe amputation in patients with diabetic foot
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目的 探讨血清降钙素原(PCT)、纤维蛋白原(FIB)水平对糖尿病足患者截趾风险的预测价值。 方法 抽取周口市中心医院2021年2月至2023年2月收治的98例糖尿病足患者为研究对象，所有患者入院后均接受一般治疗及对症治疗。根据住院期间患者是否接受截趾治疗，将患者分为截趾组与未截趾组。统计患者性别、年龄、糖尿病病程、糖尿病足病程、既往吸烟史、合并基础性疾病、溃疡深度、Wagner分级、疾病类型等基线资料。检测患者入院时PCT、FIB及血糖、血脂指标。绘制受试者工作曲线，探讨血清PCT、FIB对糖尿病足患者截趾风险的预测价值。 结果 98例糖尿病足患者中，20例(20.41%)患者接受截趾术治疗，纳入截趾组；其余78例患者纳入未截趾组。截趾组PCT水平、FIB水平、溃疡深度深占比、Wagner分级占比与未截趾组比较，差异有统计学意义(P<0.05)；绘制受试者工作特征曲线结果显示，血清PCT、FIB水平及其联合预测的曲线下面积分别为0.788、0.783、0.879，提示PCT、FIB在糖尿病足截趾风险具有一定的预测效能，且联合预测效能最高。 结论 血清PCT、FIB对糖尿病足患者截趾风险有一定预测价值，PCT、FIB水平越高，患者截趾风险越高。 Objective To investigate the value of serum procalcitonin (PCT) and fibrinogen (FIB) in predicting the risk of toe amputation in patients with diabetic foot. Methods A total of 98 patients with diabetic foot admitted to Zhoukou Central Hospital from February 2021 to February 2023 were selected for the study. All of them received general treatment and symptomatic treatment after admission. According to performance of toe amputation treatment during hospitalization, the selected patients were divided into toe amputation group and non-toe amputation group. The baseline data, such as the gender, age, course of diabetes mellitus, course of diabetic foot, smoking history, underlying medical conditions, ulcer severity, Wagner classification, disease type, were counted. The levels of PCT, FIB, blood glucose indexes and blood lipid indexes of the patients at admission were recorded. The predictive value of serum PCT and FIB on the risk of toe amputation in patients with diabetic foot were investigated by drawing the receiver operating characteristic curve. Results Among the 98 patients with diabetic foot, 20 patients (20.41%) received toe amputation, and they were enrolled into the toe amputation group and the rest 78 patients were included in the non-toe amputation group. There were significant differences in the levels of PCT and FIB, and proportion of patients with different ulcer depths and Wagner classification between the toe amputation group and the non-toe amputation group (P<0.05). Results of receiver operating characteristic curve showed that the area under the curve of serum levels of PCT, FIB and combination of the two indexes in predicting risk of toe amputation in patients with diabetic foot were 0.788, 0.783, and 0.879, respectively it was indicated that PCT and FIB had certain efficacy in predicting the risk of toe amputation in patients with diabetic foot, and the efficacy of the combination of them was the highest. Conclusions Serum PCT and FIB have certain predictive value for the risk of toe amputation in patients with diabetic foot. The risk of toe amputation increase with the increase in levels of PCT and FIB.
Objective To investigate the value of serum procalcitonin (PCT) and fibrinogen (FIB) in predicting the risk of toe amputation in patients with diabetic foot. Methods A total of 98 patients with diabetic foot admitted to Zhoukou Central Hospital from February 2021 to February 2023 were selected for the study. All of them received general treatment and symptomatic treatment after admission. According to performance of toe amputation treatment during hospitalization, the selected patients were divided into toe amputation group and non-toe amputation group. The baseline data, such as the gender, age, course of diabetes mellitus, course of diabetic foot, smoking history, underlying medical conditions, ulcer severity, Wagner classification, disease type, were counted. The levels of PCT, FIB, blood glucose indexes and blood lipid indexes of the patients at admission were recorded. The predictive value of serum PCT and FIB on the risk of toe amputation in patients with diabetic foot were investigated by drawing the receiver operating characteristic curve. Results Among the 98 patients with diabetic foot, 20 patients (20.41%) received toe amputation, and they were enrolled into the toe amputation group and the rest 78 patients were included in the non-toe amputation group. There were significant differences in the levels of PCT and FIB, and proportion of patients with different ulcer depths and Wagner classification between the toe amputation group and the non-toe amputation group (P<0.05). Results of receiver operating characteristic curve showed that the area under the curve of serum levels of PCT, FIB and combination of the two indexes in predicting risk of toe amputation in patients with diabetic foot were 0.788, 0.783, and 0.879, respectively it was indicated that PCT and FIB had certain efficacy in predicting the risk of toe amputation in patients with diabetic foot, and the efficacy of the combination of them was the highest. Conclusions Serum PCT and FIB have certain predictive value for the risk of toe amputation in patients with diabetic foot. The risk of toe amputation increase with the increase in levels of PCT and FIB.
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