Therapeutic effec of functional endoscopic sinus surgery on chronic sinusitis and its influence on nasal ciliary transport function
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目的 探讨功能性内镜鼻窦手术治疗慢性鼻窦炎的临床疗效及对患者鼻纤毛传输功能的影响。 方法 抽取2021年9月至2022年11月驻马店市第一人民医院收治的82例慢性鼻窦炎患者为研究对象，按照随机数字表法分为对照组和观察组，每组41例。对照组实施传统手术治疗，观察组实施功能性内镜鼻窦手术治疗。比较两组临床疗效、症状改善情况[视觉模拟量表(VAS)和鼻腔鼻窦结局测量20条(SNOT-20)评分]、炎性因子[白细胞介素-8(IL-8)、白细胞介素-4(IL-4)、超敏C反应蛋白( hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素1β(IL-1β)水平]、鼻纤毛传输功能及并发症发生情况。 结果 观察组临床治疗总有效率(95.12%，39/41)高于对照组(73.17%，30/41)，P<0.05。治疗后，观察组VAS评分、SNOT-20评分低于对照组(P<0.05)，IL-8、IL-4、hs-CRP、TNF-α、IL-1β水平低于对照组(P<0.05)。观察组并发症发生率(4.88%，2/41)低于对照组(21.95%，9/41)，P<0.05。观察组鼻黏膜纤毛传输速度、鼻黏液纤毛清除速度、鼻黏液纤毛清除率分别为(11.31±2.33)mm/min、(8.56±0.48)mm/min、(79.65±4.61)%，均高于对照组的(8.55±2.02)mm/min、(6.14±0.40)mm/min、(69.72±4.46)%，P<0.05。 结论 功能性内镜鼻窦手术治疗慢性鼻窦炎效果显著，可改善临床症状，减轻机体内炎症反应，提升鼻纤毛传输功能，且并发症少，安全性高。 Objective To investigate the therapeutic effect functional endoscopic sinus surgery on chronic sinusitis, and its influence on nasal ciliary transport function. Methods A total of 82 patients with chronic sinusitis admitted to the First People’s Hospital of Zhumadian from September 2021 to November 2022 were selected as the study objects, and they were divided into control group and observation group by random number table method, with 41 cases in each group. The control group was treated by traditional surgery, and the observation group was treated by functional endoscopic sinus surgery. The clinical efficacy, symptom improvement assessed by visual analogue scale (VAS) score and sino nasal outcome test-20 (SNOT-20), levels of inflammatory factors, including interleukin-8 (IL-8), interleukin-4 (IL-4), high sensitivity C reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), nasal mucociliary transport function, and incidence of complications were compared between the two groups. Results The total effective rate in the observation group (95.12%, 39/41) was higher than that in the control group (73.17%, 30/41), P<0.05. After treatment, the VAS score and SNOT-20 score of the observation group was lower than that of the control group (P<0.05). The levels of IL-8, IL-4, hs-CRP, TNF-α and IL-1β in the observation group were lower than those in the control group (P<0.05). The complication rate of the observation group (4.88%, 2/41) was lower than that of the control group (21.95%, 9/41),P<0.05. The nasal mucociliary transport rate, nasal mucociliary clearance speed, and nasal mucociliary clearance rate in the observation group were (11.31±2.33) mm/min, (8.56±0.48) mm/min and (79.65±4.61)%, respectively, which were higher than the (8.55±2.02) mm/min, (6.14±0.40) mm/min and (69.72±4.46)% in the control group (P<0.05). Conclusions Functional endoscopic sinus surgery has a significant effect in the treatment of chronic sinusitis, which can improve clinical symptoms, alleviate inflammatory response in the body, and enhance mucociliary transport function, with fewer complications but high safety.
Objective To investigate the therapeutic effect functional endoscopic sinus surgery on chronic sinusitis, and its influence on nasal ciliary transport function. Methods A total of 82 patients with chronic sinusitis admitted to the First People’s Hospital of Zhumadian from September 2021 to November 2022 were selected as the study objects, and they were divided into control group and observation group by random number table method, with 41 cases in each group. The control group was treated by traditional surgery, and the observation group was treated by functional endoscopic sinus surgery. The clinical efficacy, symptom improvement assessed by visual analogue scale (VAS) score and sino nasal outcome test-20 (SNOT-20), levels of inflammatory factors, including interleukin-8 (IL-8), interleukin-4 (IL-4), high sensitivity C reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), nasal mucociliary transport function, and incidence of complications were compared between the two groups. Results The total effective rate in the observation group (95.12%, 39/41) was higher than that in the control group (73.17%, 30/41), P<0.05. After treatment, the VAS score and SNOT-20 score of the observation group was lower than that of the control group (P<0.05). The levels of IL-8, IL-4, hs-CRP, TNF-α and IL-1β in the observation group were lower than those in the control group (P<0.05). The complication rate of the observation group (4.88%, 2/41) was lower than that of the control group (21.95%, 9/41),P<0.05. The nasal mucociliary transport rate, nasal mucociliary clearance speed, and nasal mucociliary clearance rate in the observation group were (11.31±2.33) mm/min, (8.56±0.48) mm/min and (79.65±4.61)%, respectively, which were higher than the (8.55±2.02) mm/min, (6.14±0.40) mm/min and (69.72±4.46)% in the control group (P<0.05). Conclusions Functional endoscopic sinus surgery has a significant effect in the treatment of chronic sinusitis, which can improve clinical symptoms, alleviate inflammatory response in the body, and enhance mucociliary transport function, with fewer complications but high safety.
SinusitisChronicFunctional endoscopic sinus surgeryClinical efficacyNasal mucociliary transport function
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