Role of NTproBNP, hs-cTnI and D-dimer levels in evaluation on prognosis of interventional therapy for acute myocardial infarction
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目的 分析N末端前脑钠肽(NTproBNP)、超敏肌钙蛋白(hs－cTnI)、D－二聚体水平在急性心肌梗死介入治疗患者预后评估中的应用价值。 方法 抽取2020年1月至2022年1月漯河市第二人民医院收治的116例急性心肌梗死介入治疗患者为研究对象。所有患者入院时均采集血液标本，进行NTproBNP、hs－cTnI、D－二聚体检测，随访6个月，观察患者预后情况，分析入院时NTproBNP、hs－cTnI、D－二聚体水平在急性心肌梗死介入治疗患者预后评估中的应用价值。 结果 116例急性心肌梗死介入治疗患者NTproBNP为(1 638.20±419.52)ng/L，hs－cTnI为(3.02±1.28)ng/mL，D－二聚体为(286.35±94.25)μg/L。不同年龄、Killip心功能分级、预后的急性心肌梗死介入治疗患者NTproBNP比较，差异有统计学意义(P<0.05)。不同Killip心功能分级、预后的急性心肌梗死介入治疗患者hs－cTnI、D－二聚体比较，差异有统计学意义(P<0.05)。经点二列相关性分析显示，NTproBNP与年龄、Killip心功能分级呈正相关(r>0，P<0.05)，与预后呈负相关(r<0，P<0.05)。经点二列相关性分析显示，hs－cTnI、D－二聚体与Killip心功能分级呈正相关(r>0，P<0.05)，与预后呈负相关(r<0，P<0.05)。绘制受试者工作特征曲线结果显示，NTproBNP、hs－cTnI、D－二聚体评估急性心肌梗死介入治疗患者预后的曲线下面积均>0.7，具有一定评估价值，联合评估价值更高。 结论 NTproBNP、hs－cTnI、D－二聚体水平与急性心肌梗死介入治疗患者预后密切相关，在预后评估中具有重要价值。 Objective To analyze the role of N-terminal pro brain natriuretic peptide (NTproBNP), hypersensitive troponin (hs-cTnI) and D-dimer levels in evaluation on prognosis of interventional therapy for acute myocardial infarction. Methods A total of 116 patients with acute myocardial infarction were treated in Luohe Second People’s Hospital from January 2020 to January 2022. Blood samples were collected from all selected patients at admission for NTproBNP, hs-cTnI and D-dimer testings. The patients were followed up for 6 months to observe the prognosis and analyze the application value of levels of NTproBNP, hs-cTnI and D-dimer in evaluating prognosis of interventional therapy for acute myocardial infarction. Results The levels of NTproBNP, hs-cTnI and D-dimer of the 116 patients with acute myocardial infarction were (1 638.20±419.52) ng/L, (3.02±1.28) ng/mL and (286.35±94.25) μg/L, respectively. There were significant differences in level of NTproBNP among acute myocardial infarction patients with different ages, with different Killip cardiac function grades and with different prognoses after interventional therapy ( P<0.05). There were significant differences in levels of hs-cTnI and D-dimer among acute myocardial infarction patients with different Killip cardiac function grades and with different prognoses (P<0.05). Results of point-biserial correlation test showed that NTproBNP was positively correlated with age and Killip cardiac function grade (r>0,P<0.05), and was negatively correlated with prognosis (r<0,P<0.05). Results of point-biserial correlation test showed that hs-cTnI and D-dimer were positively correlated with Killip cardiac function grade (r>0,P<0.05), and were negatively correlated with prognosis (r<0,P<0.05). Results of receiver operating characteristic curve showed that the area under the curve of NTproBNP, hs-cTnI and D-dimer in evaluating the prognosis of interventional therapy for acute myocardial infarction were all >0.7, which had a certain evaluation value moreover, the evaluation value of combination of them was higher. Conclusions The levels of NTproBNP, hs-cTnI and D-dimer are closely related to the prognosis of interventional therapy for acute myocardial infarction, and have important value in prognosis evaluation.
Objective To analyze the role of N-terminal pro brain natriuretic peptide (NTproBNP), hypersensitive troponin (hs-cTnI) and D-dimer levels in evaluation on prognosis of interventional therapy for acute myocardial infarction. Methods A total of 116 patients with acute myocardial infarction were treated in Luohe Second People’s Hospital from January 2020 to January 2022. Blood samples were collected from all selected patients at admission for NTproBNP, hs-cTnI and D-dimer testings. The patients were followed up for 6 months to observe the prognosis and analyze the application value of levels of NTproBNP, hs-cTnI and D-dimer in evaluating prognosis of interventional therapy for acute myocardial infarction. Results The levels of NTproBNP, hs-cTnI and D-dimer of the 116 patients with acute myocardial infarction were (1 638.20±419.52) ng/L, (3.02±1.28) ng/mL and (286.35±94.25) μg/L, respectively. There were significant differences in level of NTproBNP among acute myocardial infarction patients with different ages, with different Killip cardiac function grades and with different prognoses after interventional therapy ( P<0.05). There were significant differences in levels of hs-cTnI and D-dimer among acute myocardial infarction patients with different Killip cardiac function grades and with different prognoses (P<0.05). Results of point-biserial correlation test showed that NTproBNP was positively correlated with age and Killip cardiac function grade (r>0,P<0.05), and was negatively correlated with prognosis (r<0,P<0.05). Results of point-biserial correlation test showed that hs-cTnI and D-dimer were positively correlated with Killip cardiac function grade (r>0,P<0.05), and were negatively correlated with prognosis (r<0,P<0.05). Results of receiver operating characteristic curve showed that the area under the curve of NTproBNP, hs-cTnI and D-dimer in evaluating the prognosis of interventional therapy for acute myocardial infarction were all >0.7, which had a certain evaluation value moreover, the evaluation value of combination of them was higher. Conclusions The levels of NTproBNP, hs-cTnI and D-dimer are closely related to the prognosis of interventional therapy for acute myocardial infarction, and have important value in prognosis evaluation.
Myocardial infarctionInterventional therapyN-terminal pro brain natriuretic peptideHypersensitive troponinD-dimer
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