Clinical significance of platelet parameters and coagulation parameters testing for gestational diabetes
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目的 探讨妊娠期糖尿病(GDM)患者血小板参数及凝血指标检验的临床意义。 方法 随机对照研究。抽取2021年1月至2022年10月西安第一医院收治的100例GDM患者为观察组，另抽取同期100例健康孕妇为对照组。均于孕中期采血开展血小板参数、凝血指标检测，比较两组血小板参数[血小板计数(PLT)、血小板平均体积(MPV)、血小板分布宽度(PDW)]、凝血指标[凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、D－二聚体(D－D)、纤维蛋白原(FIB)]。随访至分娩，比较两组不良妊娠结局发生率。采用Pearson相关性分析血小板参数、凝血指标与不良妊娠结局的相关性。 结果 观察组PLT低于对照组，MPV、PDW高于对照组，差异有统计学意义(P<0.05)。观察组TT、APTT、PT短于对照组，FIB、D－D高于对照组，差异有统计学意义(P<0.05)。观察组不良妊娠结局发生率(32.00%，32/100)高于对照组(6.00%，6/100)，差异有统计学意义(χ2＝21.96，P<0.001)。Pearson相关性分析结果显示，PLT、TT、APTT、PT与GDM患者不良妊娠结局呈负相关(r＝－0.42、－0.42、－0.44、－0.44，P<0.05)，MPV、PDW、FIB、D－D与GDM患者不良妊娠结局呈正相关(r＝0.40、0.42、0.43、0.46，P<0.05)。 结论 GDM患者血小板参数、凝血指标可出现异常变化，会增加不良妊娠结局风险。 Objective To investigate the clinical significance of platelet parameters and coagulation parameters testing for gestational diabetes (GDM). Methods A total of 100 patients with GDM admitted to Xi’an First Hospital from January 2021 to October 2022 were selected as the observation group for the randomized controlled study. And 100 healthy pregnant women during the same period were selected as the control group. Blood samples were collected during mid pregnancy for platelet parameters and coagulation parameters testings. The platelet parameters, including platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW), and coagulation parameters, including thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT), D-dimer (D-D) and fibrinogen (FIB), were compared between the two groups. Patients in the two groups were followed up until delivery. The incidence of poor pregnancy outcomes of the two groups were compared. Pearson correlation analysis was used to investigate the correlations of platelet parameters and coagulation parameters with poor pregnancy outcomes. Results Compared with the control group, the observation group had lower PLT, higher MPV and higher PDW (P<0.05). The TT, APTT, and PT of the observation group were shorter than those of the control group, while FIB and D-D of the observation group were higher than those of the control group (P<0.05). The incidence of poor pregnancy outcomes of the observation group (32.00%, 32/100) was higher than that of the control group (6.00%, 6/100), and the difference was significant (χ2=21.96, P<0.001). Pearson correlation analysis revealed that PLT, TT, APTT and PT were negatively correlated with poor pregnancy outcomes in patients with GDM (r=-0.42, -0.42, -0.44, -0.44 P<0.05) MPV, PDW, FIB and D-D were positively correlated with poor pregnancy outcomes in patients with GDM (r=0.40, 0.42, 0.43, 0.46 P<0.05). Conclusions Patients with GDM may experience abnormal changes in platelet parameters and coagulation parameters, which can increase the risk of poor pregnancy outcomes.
Objective To investigate the clinical significance of platelet parameters and coagulation parameters testing for gestational diabetes (GDM). Methods A total of 100 patients with GDM admitted to Xi’an First Hospital from January 2021 to October 2022 were selected as the observation group for the randomized controlled study. And 100 healthy pregnant women during the same period were selected as the control group. Blood samples were collected during mid pregnancy for platelet parameters and coagulation parameters testings. The platelet parameters, including platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW), and coagulation parameters, including thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT), D-dimer (D-D) and fibrinogen (FIB), were compared between the two groups. Patients in the two groups were followed up until delivery. The incidence of poor pregnancy outcomes of the two groups were compared. Pearson correlation analysis was used to investigate the correlations of platelet parameters and coagulation parameters with poor pregnancy outcomes. Results Compared with the control group, the observation group had lower PLT, higher MPV and higher PDW (P<0.05). The TT, APTT, and PT of the observation group were shorter than those of the control group, while FIB and D-D of the observation group were higher than those of the control group (P<0.05). The incidence of poor pregnancy outcomes of the observation group (32.00%, 32/100) was higher than that of the control group (6.00%, 6/100), and the difference was significant (χ2=21.96, P<0.001). Pearson correlation analysis revealed that PLT, TT, APTT and PT were negatively correlated with poor pregnancy outcomes in patients with GDM (r=-0.42, -0.42, -0.44, -0.44 P<0.05) MPV, PDW, FIB and D-D were positively correlated with poor pregnancy outcomes in patients with GDM (r=0.40, 0.42, 0.43, 0.46 P<0.05). Conclusions Patients with GDM may experience abnormal changes in platelet parameters and coagulation parameters, which can increase the risk of poor pregnancy outcomes.
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