Study on the process of a traditional chinese medicine compound cataplasm for treating eczema
Objective Optimize the prescription and process of a traditional Chinese medicine compound cata-plasm for treating eczema.Methods Using sensory evaluation score as evaluation indicator,single factor experi-ments and orthogonal experiments were conducted to determine the amount of polyvinyl alcohol,gelatin,sodium carboxymethyl cellulose and glycerol added to the cataplasm's matrix and their impact on performance of matrix.And using the false seed coat of Torreya grandis,Cynanchum paniculatum and Fructus cnidii as the main raw materials,sensory evaluation score was also used as the evaluation standard to determine the optimal drug loading of the traditional Chinese medicine compound in the cataplasm,and to optimize the formula of the traditional Chinese medicine compound cataplasm.Results The comprehensive order of the effects of various factors on the uniformity,spreadability,skin adhesion,repeated adhesiveness,residual amount of the paste and degree of pen-etration of the cataplasm's matrix is as follows:sodium carboxymethyl cellulose＞gelatin＞polyvinyl alcohol＞glycerol.The optimal formula of cataplasm is as follows:3.50 g polyvinyl alcohol,4.00 g gelatin,1.50 g so-dium carboxymethyl cellulose,10.00 g glycerol and 30％drug loading.Conclusion According to the optimized formula,the prepared cataplasm has good formability,moderate spreadability and skin adhesion,and no residue after peeling off the skin.
cataplasmoptimization of prescriptionsingle factor experimentorthogonal experiment
国家科技期刊平台
NSTL
万方数据
维普
