Research progress of Fritillaria thunbergii Miq in reversing drug resistance of malignant tumor
In the process of cancer therapy,the emergence of drug resistance will greatly reduce the therapeutic effect.Effectively reversing drug resistance of cancer cells is the key to improving the prognosis of patients.Mod-ern pharmacological studies have shown that Fritillaria thunbergii Miq can reverse the drug resistance of cancer cells,which is often used in the research of leukemia,breast cancer,liver cancer and other malignant tumors.Thechemical compositions of Fritillaria thunbergii Miq can reverse drug resistance in a variety of cancer cells by mechanisms such as inhibiting the expression of P-glycoprotein,reducing drug efflux and increasing intracellular drug concentration.They can also induce apoptosis of cancer cells by arresting cell cycle,thereby increasing the concentration of anticancer drugs in cancer cells and reversing the drug resistance of cancer cells.In this paper,the chemical composition of Fritillaria thunbergii Miq and its reversal of drug resistance of cancer cells in recent years were reviewed,so as to promote the in-depth study of Fritillaria thunbergii Miq and provide reliable basis for subsequent clinical application.
国家科技期刊平台
NSTL
万方数据
维普
