浙贝母逆转恶性肿瘤耐药的研究进展
Research progress of Fritillaria thunbergii Miq in reversing drug resistance of malignant tumor
刘万青 1董语迪 2罗清1
作者信息
- 1. 遵义医科大学附属医院病理科,贵州遵义 563099;遵义医科大学附属医院临床医学公共实验中心,贵州遵义 563099
- 2. 遵义医科大学附属医院临床医学公共实验中心,贵州遵义 563099
- 折叠
摘要
肿瘤治疗过程中,耐药的出现会大大降低治疗效果,有效逆转肿瘤细胞耐药是改善患者预后的关键.现代药理研究表明,浙贝母具有逆转肿瘤细胞耐药的作用,常用于白血病、乳腺癌、肝癌等多种恶性肿瘤的研究中.浙贝母中的化学成分可通过抑制P-糖蛋白(P-gp)的表达、减少药物外排、增加胞内药物浓度等机制,在多种肿瘤细胞中实现其逆转耐药的作用;亦可通过阻滞细胞周期诱导肿瘤细胞凋亡,进而增加肿瘤细胞内抗癌药物浓度,逆转肿瘤细胞耐药.现通过对近年来浙贝母化学成分及其逆转肿瘤细胞耐药的相关研究进行综述,以期促进浙贝母的深入研究,为后续应用于临床提供可靠的依据.
Abstract
In the process of cancer therapy,the emergence of drug resistance will greatly reduce the therapeutic effect.Effectively reversing drug resistance of cancer cells is the key to improving the prognosis of patients.Mod-ern pharmacological studies have shown that Fritillaria thunbergii Miq can reverse the drug resistance of cancer cells,which is often used in the research of leukemia,breast cancer,liver cancer and other malignant tumors.Thechemical compositions of Fritillaria thunbergii Miq can reverse drug resistance in a variety of cancer cells by mechanisms such as inhibiting the expression of P-glycoprotein,reducing drug efflux and increasing intracellular drug concentration.They can also induce apoptosis of cancer cells by arresting cell cycle,thereby increasing the concentration of anticancer drugs in cancer cells and reversing the drug resistance of cancer cells.In this paper,the chemical composition of Fritillaria thunbergii Miq and its reversal of drug resistance of cancer cells in recent years were reviewed,so as to promote the in-depth study of Fritillaria thunbergii Miq and provide reliable basis for subsequent clinical application.
关键词
浙贝母/恶性肿瘤/逆转耐药/生物碱Key words
Fritillaria thunbergii Miq/malignant tumor/drug resistance/alkaloid引用本文复制引用
基金项目
国家自然科学基金(81860469)
贵州省科技计划(黔合科基础-ZK2023一般554)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据