The effect of antibiotics on chemotherapy combined with immunotherapy of advanced urothelial carcinoma
Objective This study aimed to investigate the influence of antibiotics on the clinical efficacy of chemotherapy combined with immunotherapy in patients with advanced urothelial carcinoma.Methods A retro-spective analysis was conducted on 71 patients diagnosed with advanced urothelial carcinoma who received chem-otherapy combined with immunotherapy in our hospital between August 2020 and December 2022.The patients were divided into two groups:Group A(patients who received antibiotics)and Group B(patients who did not receive antibiotics).The baseline characteristics and survival analyses were compared between the two groups.Results There were no statistically significant differences in baseline clinical characteristics between the two groups(P＞0.05).The median progression-free survival(mPFS)in Group A was 6 months(95％CI:4.92-7.08),which was significantly lower compared to 8 months(95％CI:5.67-10.34)in Group B(P=0.001).Multivariate Cox regression analysis demonstrated that the use of antibiotics was an independent factor affecting PFS(HR=2.11,95％CI 1.17-3.81,P=0.014).Conclusion Antibiotics can impact the clinical efficacy of chem-otherapy combined with immunotherapy in patients with advanced urothelial carcinoma,resulting in shortened progression-free survival(PFS).Therefore,the use of antibiotics should be cautiously and appropriately consid-ered in clinical practice.
antibioticsurothelial carcinomaimmune checkpoint inhibitorschemotherapy combined with im-munotherapy
万方数据
维普
