Efficacy and safety of H1 antihistamines combination therapy for allergic rhinitis
Objective To perform a scoping review to analyze the common treatment regimens of H1 antihista-mines(AHs)combination therapy for allergic rhinitis(AR)and evaluate their efficacy and safety.Methods We conducted a comprehensive search of 8 databases from both China and abroad in May 2023,following the meth-odological framework proposed by Arksey and O'Malley.The quality of the included studies was rigorously eval-uated.Results A total of 70 studies,covering 8 combination therapy regimens were included from 8 207 related literatures.Sixty-seven studies reported that 2 AHs combination therapy was more effective than monotherapy,and 3 studies indicated that 2 AHs combination therapy was more effective and safer than 3 AHs combination therapy or monotherapy.Thirty-three studies concluded that 2 AHs combination therapy had a better safety pro-file than single AHs therapy.Additionally,1 study found that 3 AHs combination therapy was more effective than monotherapy,but it was associated with a higher incidence of adverse drug reactions(ADRs).Conclusion Based on the current evidence,2 AHs combination therapy has demonstrated superior efficacy and safety com-pared to monotherapy or 3 AHs combination therapy for AR.Specifically,the combination of Azelastine nasal spray and Desloratadine tablets has emerged as the most commonly utilized treatment regimen in the review.
allergic rhinitisadverse drug reactionscombination therapyefficacyH1 antihistamines
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