Objective To perform a scoping review to analyze the common treatment regimens of H1 antihista-mines(AHs)combination therapy for allergic rhinitis(AR)and evaluate their efficacy and safety.Methods We conducted a comprehensive search of 8 databases from both China and abroad in May 2023,following the meth-odological framework proposed by Arksey and O'Malley.The quality of the included studies was rigorously eval-uated.Results A total of 70 studies,covering 8 combination therapy regimens were included from 8 207 related literatures.Sixty-seven studies reported that 2 AHs combination therapy was more effective than monotherapy,and 3 studies indicated that 2 AHs combination therapy was more effective and safer than 3 AHs combination therapy or monotherapy.Thirty-three studies concluded that 2 AHs combination therapy had a better safety pro-file than single AHs therapy.Additionally,1 study found that 3 AHs combination therapy was more effective than monotherapy,but it was associated with a higher incidence of adverse drug reactions(ADRs).Conclusion Based on the current evidence,2 AHs combination therapy has demonstrated superior efficacy and safety com-pared to monotherapy or 3 AHs combination therapy for AR.Specifically,the combination of Azelastine nasal spray and Desloratadine tablets has emerged as the most commonly utilized treatment regimen in the review.
关键词
过敏性鼻炎/药物不良反应/联合治疗/疗效/H1抗组胺药
Key words
allergic rhinitis/adverse drug reactions/combination therapy/efficacy/H1 antihistamines
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