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绞股蓝中达玛烷型四环三萜皂苷元的波谱学特征

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达玛烷型四环三萜皂苷类成分是绞股蓝中主要有效成分,该类化学成分在人参、三七、西洋参等其他药用植物中也有分布,因其具有抗肿瘤、降血脂血糖等广泛的药理活性,一直是中药领域的研究热点。由于达玛烷型四环三萜皂苷元部分在核磁共振波谱中存在大量的亚甲基、次甲基信号叠加,其化学结构鉴定难度较大。本文拟对已报道的绞股蓝中达玛烷型四环三萜皂苷类成分的波谱学数据进行归纳,总结出绞股蓝皂苷元的结构特点及其波谱学特征,为绞股蓝乃至其他药材中达玛烷型四环三萜皂苷类成分的结构解析提供科学依据。
A review on spectral characteristics of dammarane-type triterpenoid sapo-genins from Gynostemma pentaphyllum
Dammarane-type triterpenoids are believed to be major bioactive ingredients derived from Gynostem-ma pentaphyllum,this class of chemical components is also widely found in other medical plants such as Panax ginseng,Panax notoginseng,Panax quinquefolium L.Besides,it has been a hotspot of research in the field of traditional Chinese medicine due to its wide range of pharmacological activities such as antitumor and hypolipi-demic.The identification of the chemical structure of the dammarane-type triterpenoid saponin meta-fraction is difficult due to the presence of a large number of methene and methine signals superimposed in the NMR spec-trum.This review aims to summarize the structural features and spectral characteristics of sapogenins based on the spectral data of the reported dammarane-type triterpenes in Gynostemma pentaphyllum.It may provide scien-tific basis for the structural analysis of dammarane-type triterpenoid saponins in Gynostemma pentaphyllum and e-ven in other medicinal herbs.

gynostemma pentaphyllumdammarane-type triterpenoidsspectral characteristicsnuclear magnet-ic resonance

王显婷、杜艺玫、谭道鹏

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遵义医科大学药学院,贵州金钗石斛产业发展关键技术工程中心,贵州遵义 563006

绞股蓝 达玛烷型皂苷 波谱学 核磁共振

国家自然科学基金遵义医科大学研究生科研基金

82060649ZYK197

2024

遵义医科大学学报
遵义医科大学

遵义医科大学学报

CSTPCD
ISSN:2096-8159
年,卷(期):2024.47(3)
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