目前纤维化疾病的治疗仍是世界性难题,其带来的医疗负担不容小觑.纤维化疾病病因涉及创伤、感染、代谢或自身免疫等多方面,研究发现纤维化疾病有着共同的病理基础,但尚未阐明其具体的分子机制.由于蛋白质是生物学行为的重要参与者,因此在翻译水平探究纤维化疾病的分子机制可能是有效的研究方案.本综述基于数据平台(PubMed、Web of science等)检索文献,回顾近5年关于翻译水平调控纤维化的分子机制研究进展,拟通过总结推动人们对纤维化分子机制的认识.我们总结了在翻译的起始、延伸以及终止阶段对纤维化的发生有重要影响的因子.例如翻译起始因子家族的在翻译起始过程中的关键影响,延伸因子在肽链延伸过程中的重要作用,正确识别终止密码子在翻译终止过程中的重要意义.除此之外,我们还总结了其他在翻译水平有重要作用的因子,例如微小RNA、转运RNA、小核糖体RNA及长非编码RNA等.
Abstract
At present,the treatment of fibrotic diseases is still a worldwide problem,and the medical burden caused by fibrotic diseases cannot be underestimated.Its etiology involves trauma,infection,metabolism or auto-immunity.Studies have found that fibrotic diseases have a common pathological basis.However,its molecular mechanism cannot be elucidated at present.Given the crucial role of proteins in biological processes,investiga-ting the translational level may offer an effective research approach to unravel the molecular mechanisms of fibrot-ic diseases.This review is based on comprehensive literature retrieval from data platforms such as PubMed and Web of Science.Its objective is to provide an overview of recent advancements in translationally regulated molec-ular mechanism of fibrosis over the past five years and enhance our understanding in this field.We summarize the factors that play important roles in the initiation,elongation and termination of translation in the development of fibrosis.For example,the key role of the eukaryotic initiation factor family in translation initiation,the impor-tant role of elongation factors in peptide chain elongation,and the importance of correct recognition of stop co-dons in translation termination.In addition,we also summarize other important factors at the level of translation,such as miRNA,tRNA,tsRNA and lcnRNA.
维普
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