Retrospective analysis on the treatment of drug induced liver injury in acute leukemia patients
Objective This research aims to explore the influential factors for drug-induced liver injury(DILI)in acute leukemia(AL)patients through retrospective analysis.Methods The information of AL patients with DILI hospitalized in a hospital from January 2015 to December 2020 were collected.Chi-square test was utilized to identify influential factors(age,gender,type of AL,state of DILI,type of DILI,indicators of liver function,hepatoprotective drugs,outcome)for DILI treatment of AL patients.Chi-square test was utilized for the correla-tion analysis.Results A total of 927 AL patients were enrolled,of which 84 patients had DILI and received med-ication with the effective rate of 72％.The influential factors that significantly correlated with patient outcomes were DILI types and drug usages,respectively(P＜0.05).Abnormal liver function was identified as the major type of DILI(80.67％)but with less effective ratio(68.2％).A total of 13 hepatoprotective drugs were classi-fied into 6 categories and used in the DILI treatment.The medical therapy alone is the most common type of drug usages(62％).The mostly common drugs were reduced glutathione(45.0％),magnesium isoglycyrrhizinate(27.10％),and ornithine aspartate(27.10％).Conclusion Based on the data of the current study,DILI has good prognosis in most AL hospitalized patients.Evidence-based treatment and combinational usages of hepato-protective drugs play a significant role in the treatment of DILI.A special attention should be still paid on the ex-istence of clinical abuse of hepatoprotective drugs.
acute leukemiadrug induced liver injuryretrospective analysishepatoprotective drug
国家科技期刊平台
NSTL
万方数据
维普
