Harm and response strategies of high-alcohol-producing Klebsiella pneumoniae
High-alcohol-producing Klebsiella pneumoniae(HiAlc Kpn)can produce large amounts of endoge-nous alcohol in the intestines of patients,which is a new cause of nonalcoholic fatty liver disease(NAFLD)and seriously endangers human health.Antibiotic treatment is the main way to deal with bacterial infections,but the antibiotic resistance is becoming increasingly serious in K.pneumoniae,and antibiotics often disrupt the balance of human gut microbiota.Phage therapy is expected to treat NAFLD by targeted killing of HiAlc Kpn without de-stroying healthy intestinal microbiota.At the same time,we should actively search for targets that affect the alco-hol-producing capacity of HiAlc Kpn,so as to provide theoretical basis for the development of anti-virulence drugs.This paper mainly describes the harmfulness of HiAlc Kpn and puts forward some strategies to treat HiAlc Kpn infection.
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