Progress of exosome-derived circular RNA regulation on tumor and immune cells
Exosomes(Exo)are nanoscale vesicles secreted by cells,which can influence intercellular commu-nication by carrying various substances and regulate the occurrence and development of tumors in the tumor mi-croenvironment(TME).Circular RNA(circRNA)is a type of non-coding RNA molecule with a unique struc-ture that makes it difficult to degrade in vivo.In recent years,the function of circRNA in tumor progression has gradually been revealed,and a large number of abnormally expressed circRNAs have been detected in Exo.Many studies have shown that Exo-derived circRNA(Exo-circRNA)can directly or indirectly participate in the regulation of tumor cell proliferation,metastasis,metabolism,and drug resistance in TME.At the same time,Exo-circRNA in TME can also regulate the activation and function of immune cells,affecting tumor im-munotherapy.However,previous studies primarily focused on summarizing the advancements in Exo-circRNA regulation of tumor cells,limited research involved in its regulation on immune cells and most of them predomi-nantly concentrated on summarizing the progress of Exo-circRNA on regulating CD8+T cell function.The inno-vation of this study lies in it not only reviewed the research on Exo-circRNA in regulating tumor cells but also delved into its regulation of various immune cells in the TME,including CD8+T cells,and their specific mecha-nisms.Additionally,we provided insights into the potential clinical applications of Exo-circRNA in tumor ther-apy and immunotherapy,thereby offering a theoretical basis for its role as a diagnostic marker and therapeutic target in cancer.
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