Research progress on the application of modified mesenchymal stem cells in neurodegenerative diseases
Mesenchymal stem cells(MSCs)are cells that can be isolated from various biological tissues such as bone marrow and adipose tissue,as well as the umbilical cord and placenta.MSCs have the ability of exten-sive multiplication and multi-way differentiation,and have the functions of nutrition,nesting,migration and im-munoregulation.In recent years,MSCs have been widely used in the treatment of degenerative diseases of the nervous system.And the therapeutic effect of MSCs modified with different methods is greatly improved.The sur-vival rate of transplanted MSCs cells is increased,and their proliferation and differentiation abilities are also im-proved,a variety of methods for modifying MSCs such as genetic engineering,small molecule pretreatment,tumor virus treatment and other methods are used to modify MSCs.This article reviews the different modification methods of MSCs and their applications in the study of neurodegenerative diseases.
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