首页|呼吸道合胞病毒感染相关的lncRNA研究进展

呼吸道合胞病毒感染相关的lncRNA研究进展

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呼吸道合胞病毒(RSV)引起的肺部感染是人类健康的一大负担,至今无特异的疫苗和(或)抗病毒药物进行有效的防治,并且发病机制不完全清楚.长链非编码RNA(lncRNA)是病毒感染过程中宿主-病毒相互作用的关键调节分子,有研究发现lncRNA在RSV感染后出现差异性表达,部分通过促进宿主的免疫细胞成熟、调控免疫分子、调控RSV的基因或蛋白表达来影响RSV的复制,很可能是RSV感染诊断的潜在生物标记和(或)治疗靶点.本文对RSV感染进程中可能有重要作用的lncRNA进行综述,以加深对lncRNA参与的RSV感染机制的理解.
Research progress on lncRNAs associated with respiratory syncytial virus in-fection
Respiratory syncytial virus(RSV)induced pulmonary infections pose a significant burden on human health,which have no specific vaccines or antiviral drugs available for prevention and treatment to date,and the pathogenesis remains incompletely understood.Long non-coding RNAs(lncRNAs)serve as crucial regulatory molecules in host-virus interactions during viral infections.Studies have found differential expression of lncRNAs following RSV infection,some of which may influence RSV replication by promoting host immune cell matura-tion,regulating immune molecules,or modulating the expression of RSV genes or proteins.They are likely to be potential biomarkers for RSV infection diagnosis and/or therapeutic targets.This review summarizes lncRNAs that may play important roles in the progression of RSV infection,aiming to deepen the understanding of the mechanisms through which lncRNAs participate in RSV infection.

long non-coding RNAinfectionimmunerespiratory syncytial virus

刘艺、李竹、刘代顺

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遵义医科大学第五附属医院呼吸内科,广东珠海 519000

长链非编码RNA 感染 免疫 呼吸道合胞病毒

国家自然科学基金贵州省科技计划

82360001黔科合基础-ZK2022一般581

2024

遵义医科大学学报
遵义医科大学

遵义医科大学学报

CSTPCD
ISSN:2096-8159
年,卷(期):2024.47(5)