摘要
目的 研究联合甘草养阴汤(GCNY)的中西医结合治疗对类风湿性关节炎(RA)的疗效.方法 采用真实世界研究进行自身历史对照,纳入70例已确诊的RA患者.对照组为前4个月西医常规治疗,观察组为后4个月在西医常规治疗基础上加服GCNY.每两月随访评估1次,检测血沉(ESR)、C反应蛋白(CRP)、类风湿因子(RF)、血小板计数(PLT)、血红蛋白含量(HGB)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、血尿素(BUN)、血肌酐(Scr)水平.采用广义估计方程对两组指标进行统计分析,比较两组不良反应发生率.结果 观察组ESR在第2、4月时显著低于对照组[(43.6±29.4)/(67.9±34.1),P＜0.001;(44.9±30.7)/(62.3±34.2),P=0.010];观察组 CRP 在 2、4 月时显著低于对照组[(10.4±17.8)/(26.5±37.8),P=0.009;(10.4±10.3)/(18.0±24.9),P=0.037];观察组 PLT 在基线、2 月时显著低于对照组;两组HGB、RF、ALT、AST、Scr、BUN差异均无统计学意义.观察组不良反应发生率明显低于对照组.结论 联合GCNY的中西医结合治疗有助于降低RA相关炎症指标,且安全性好.
Abstract
Objective Exploring the efficacy of integrative therapy in combination with Gancao nurishing-Yin decoction(GCNY)for rheumatoid arthritis.Methods A clinical study involving 70 patients diagnosed with rheu-matoid arthritis was conducted to use own-history as control.The control group was treated with conventional Western medicine for the first 4 months,and the observation group was given GCNY on top of conventional West-ern medicine for the second 4 months.Bimonthly follow-up assessments included erythrocyte sedimentation rate,C-reactive protein,rheumatoid factor,platelet,hemoglobin,alanine aminotransferase,aspartate aminotransami-nase,blood urea nitrogen,and serum creatinine levels.Statistical analysis was performed using generalized esti-mating equations to compare the indicators between the two groups.The incidence of adverse reactions was com-pared using the chi-square test.Results Erythrocyte sedimentation rate was significantly lower in the observation group compared to the control group at months 2 and 4[(43.6±29.4)vs.(67.9±34.1),P＜0.001;(44.9±30.7)vs.(62.3±34.2),P=0.010].C-reactive protein was significantly lower in the observation group compared to the control group at months 2 and 4[(10.4±17.8)vs.(26.5±37.8),P=0.009;(10.4±10.3)vs.(18.0±24.9),P=0.037].Platelet was significantly lower in the observation group compared to the control group at baseline and months 2.The differences in hemoglobin,rheumatoid factor,alanine amin-otransferase,aspartate aminotransaminase,serum creatinine,and blood urea nitrogen between the two groups were not statistically significant.The observation group had significantly fewer adverse reactions compared to the control group.Conclusion Integrative therapy in combination with GCNY helps to reduce RA-related inflammato-ry markers with a good safety profile.
基金项目
贵州省科技计划(黔科合基础—ZK2024一般304)
遵义医科大学博士科研启动基金(院字202303)
遵义市科技计划(遵义市科合HZ字2023296)
维普
万方数据