Heart failure with preserved ejection fraction accounts for 40％-71％of heart failure,is amultisystem disease involving the heart,kidneys,lungs,vascular system and adipose tissue,and seriously affects patients'quality of life.Recently,with the continuous improvement of medical research,its clinical treatment has achieved certain effects,but the prognosis of patients is still poor,the recurrence rate is increased and the quality of life is decreased.This article reviews the recent domestic and foreign research reports on heart failure with preserved e-jection fraction,and finds that its pathological and physiological mechanisms are mainly related to hypertension,coronary artery disease and coronary microvascular dysfunction,left ventricular insufficiency,right ventricular dysfunction and pulmonary artery disease,abnormal hormone system,obesity,systemic inflammation and meta-bolic abnormality.Diuretics,renin-angiotensin-aldosterone system(RAAS)inhibitors,sodium-glucose cotrans-porter-2 inhibitor(SGLT2i),mineralocorticoid receptor antagonist and statins are usually used for treatment.The construction of animal models of different types is expected to provide some valuable references for the clinical di-agnosis and treatment of heart failure with preserved ejection fraction.
关键词
射血分数保留型心力衰竭/病理生理机制/药物治疗/动物模型
Key words
heart failure with preserved ejection fraction/pathological and physiological mechanisms/drug therapy/animal model
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