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遵义地区单中心尿路结石成分分析

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目的 分析遵义地区尿路结石成分的特征,探讨这些特征在不同性别、年龄和结石部位之间的差异性。方法 收集遵义医科大学附属医院泌尿外科于2018年1月至2022年1月期间遵义地区13个县市1 119例具有本地籍贯并长期居住的尿路结石患者的结石样本,通过红外光谱法对其成分进行了检测,结合患者临床资料,对数据进行分析和探讨。结果 共收集1 119例结石,患者男女比例为1。59∶1,其中41~60岁患者年龄构成比例最高,男性58。87%(405/688)、女性58。47%(252/431)。结石成分研究表明,混合成分结石在总样本中的比例为67。82%(759/1 119),其中,以一水草酸钙、二水草酸钙和碳酸磷灰石的复合结石最常见,占混合成分结石的32。54%(247/759);紧随其后的是一水草酸钙与二水草酸钙的组合,占比25。82%(196/759)。单一成分结石占据了 32。17%(360/1 119),主要为一水草酸钙结石,占单一成分结石的77。22%(278/360),尿酸结石则占14。72%(53/360)。六水磷酸铵镁结石在男性中的构成比(2。91%)显著低于女性(11。14%,P<0。01)。下尿路结石的男性患病率(7。05%)显著高于女性(0。89%,P<0。01)。结论 在遵义地区,尿路结石多以成分为草酸钙和尿酸为主的混合型结石,41~60岁为高发年龄段,感染性结石女性高于男性,下尿路结石女性低于男性。
Analytical study on components of urinary calculi in Zunyi
Objective To analyze the characteristics of urinary lithiasis compositions and investigate their vari-ances from the perspective of different genders,ages and calculi locations.Methods A total of 1 119 cases were collected from patients who received treatment in the urinary department of Affiliated Hospital of Zunyi Medical University from January 2018 to January 2022.The patients were local residents from 13 counties within Zunyi and had a long-term residential history.The calculi compositions were detected by infrared spectroscopy and ana-lyzed with the patients'clinical data.Results Of all 1 119 cases,the gender ratio(male to female)is 1.59:1.Most patients are within 41-60 years old,of whom 58.87%are male(405/688)and 58.47%are female(252/431).According to the results of calculi compositions,mixed calculi make up 67.82%(759/1 119),of which combination calculi made of calcium oxalate monohydrate,calcium oxalate dihydrate and apatite carbonate are dominant,reaching 32.54%(247/759).The combination of calcium oxalate monohydrate and calcium ox-alate dihydrate makes up 25.82%(196/759).Calculi of single components make up 32.17%(360/1 119).They consist of calcium oxalate monohydrate calculi 77.22%(278/360)and uric acid calculi 14.72%(53/360).Gender analysis shows that detection rate of magnesium ammonium phosphate hexahydrate calculus is higher in female patients than in male patients(P<0.01).Meanwhile,male patients are more vulnerable to lower urina-ry calculi than the female patients(P<0.01).Conclusion In Zunyi,urinary lithiasis are mainly combination calculi of calcium oxalate calculi and uric acid calculi.The dominant age range for the occurrence of the disease is 41-60 years old.The occurrence rate of infectious calculi is higher in female patients than in male patients.The occurrence rate of lower urinary calculi is lower in female patients than in male patients.

urinary calculicomponent analysisinfrared spectroscopy

李本根、朱焓、李成、付梓峰

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遵义医科大学附属医院泌尿外科,贵州遵义 563003

尿路结石 成分分析 红外光谱

遵义市科技计划

遵市科合HZ字2022252

2024

遵义医科大学学报
遵义医科大学

遵义医科大学学报

CSTPCD
ISSN:2096-8159
年,卷(期):2024.47(8)