Research progress in the regulation of Wnt/β-catenin signaling pathway by ncRNAs in non-small cell lung cancer
Lung cancer is the malignant tumour with the highest morbidity and mortality rate in China.As a major subtype of lung cancer,non-small cell lung cancer(NSCLC)has been receiving much attention in re-search.Despite considerable progress in therapeutic approaches,the prognosis and management of NSCLC pa-tients are still poor.The Wnt/β-catenin signaling pathway plays a critical role in malignant tumours and pro-foundly influences lung cancer progression,especially in terms of migration,invasion and distant metastasis in NSCLC.Therefore,the Wnt/β-catenin pathway has been identified as one of the main targets for the treatment of NSCLC patients.Non-coding RNAs(ncRNAs),which include microRNAs,long non-coding RNAs,and circu-lar RNAs,are integral components of the epigenetic machinery important in gene regulation.They exert vital roles in a wide variety of molecular and cellular processes and regulate many signaling pathways,including the Wnt/β-catenin pathway.An intimate understanding of the regulatory molecules of ncRNAs in NSCLC develop-ment may help to identify and overcome the limitations of current therapeutic approaches and uncover potential therapeutic targets.Therefore,this paper will provide an overview of the mechanisms by which ncRNAs regulate the Wnt/β-catenin signaling pathway in NSCLC.
国家科技期刊平台
NSTL
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