非小细胞肺癌中ncRNAs对Wnt/β-catenin信号通路调控的研究进展
Research progress in the regulation of Wnt/β-catenin signaling pathway by ncRNAs in non-small cell lung cancer
王芝玉 1周立霞1
作者信息
- 1. 遵义医科大学第五附属(珠海)医院肿瘤科,广东珠海 519100
- 折叠
摘要
肺癌乃中国发病率和死亡率最高的恶性肿瘤.非小细胞肺癌(NSCLC)作为肺癌的主要亚型,其研究一直备受关注.尽管在治疗方法上取得了相当大的进展,但NSCLC患者的预后和管理仍然很差.Wnt/β-catenin信号通路在恶性肿瘤中扮演关键角色,深刻地影响着肺癌的进展,尤其是在NSCLC的迁移、侵袭与远处转移方面.因此,Wnt/β-catenin通路已被确定为NSCLC患者治疗的主要靶标之一.非编码RNAs(ncRNAs)包含微小RNAs、长链非编码RNAs和环状RNAs,是基因调控中重要的表观遗传机制组成部分,它们在各种分子和细胞过程中发挥重要作用,调节诸多信号通路,包括Wnt/β-catenin通路.深入了解ncRNAs在NSCLC发展中的调控分子,或许有助于识别并克服目前治疗方法的局限性,发掘潜在的治疗靶点.因此,本文将对NSCLC中ncRNAs调控Wnt/β-catenin信号通路的机制进行综述.
Abstract
Lung cancer is the malignant tumour with the highest morbidity and mortality rate in China.As a major subtype of lung cancer,non-small cell lung cancer(NSCLC)has been receiving much attention in re-search.Despite considerable progress in therapeutic approaches,the prognosis and management of NSCLC pa-tients are still poor.The Wnt/β-catenin signaling pathway plays a critical role in malignant tumours and pro-foundly influences lung cancer progression,especially in terms of migration,invasion and distant metastasis in NSCLC.Therefore,the Wnt/β-catenin pathway has been identified as one of the main targets for the treatment of NSCLC patients.Non-coding RNAs(ncRNAs),which include microRNAs,long non-coding RNAs,and circu-lar RNAs,are integral components of the epigenetic machinery important in gene regulation.They exert vital roles in a wide variety of molecular and cellular processes and regulate many signaling pathways,including the Wnt/β-catenin pathway.An intimate understanding of the regulatory molecules of ncRNAs in NSCLC develop-ment may help to identify and overcome the limitations of current therapeutic approaches and uncover potential therapeutic targets.Therefore,this paper will provide an overview of the mechanisms by which ncRNAs regulate the Wnt/β-catenin signaling pathway in NSCLC.
关键词
非小细胞肺癌/Wnt/β-catenin/信号通路/非编码RNAsKey words
non-small cell lung cancer/wnt/β-catenin/signaling pathway/non-coding RNAs引用本文复制引用
基金项目
国家自然科学基金(82360874)
贵州省科技计划(黔科合基础-ZK2021一般543)
出版年
2024
国家科技期刊平台
NSTL
万方数据