The Trim(Tripartite Motif-containing)protein family comprises a group of proteins that possess highly conserved domains and exhibit extensive biological activities.These proteins play pivotal roles in numerous crucial biological processes,including cell proliferation,development,and apoptosis.Among the members of this family,Trim21 possesses E3 ubiquitin ligase activity,which enables it to regulate innate and adaptive immu-nity by participating in the ubiquitination and degradation of proteins.Increasing research has demonstrated that abnormal expression of Trim21 plays diverse roles in various tumors,closely associated with their occurrence and progression.To gain a deeper understanding of the mechanisms of Trim21's role in tumorigenesis and develop-ment,and to provide theoretical foundations for future therapeutic strategies,this article comprehensively reviews the research progress on Trim21's regulation of tumor proliferation,invasion,drug resistance,and immune mod-ulation.
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