Application of CRISPR/Cas system based detection technology in common pathogens of infectious diseases in the elderly
Infectious diseases in the elderly are one of the leading causes of death among elderly patients world-wide.Due to the decreased immunity and chronic underlying diseases in elderly patients,the infection factors are more complex and their clinical manifestations are different.Early,rapid and accurate identification of infectious pathogens can provide meaningful information forclinical targeted anti-infection treatment,which helps to reduce complications and mortality in elderly patients.There are disadvantages such as relying on live bacteria,long de-tection time,high access conditions for detection personnel or relying on expensive instruments for the traditional pathogen detection methods.With the development of CRISPR/Cas system in microbial detection,the applica-tion of CRISPR/Cas detection technology in pathogens of infectious diseases in the elderly has become increasing-ly prominent,which can not only efficiently and accurately identify pathogens,in particular,it has important ref-erence value for the auxiliary diagnosis of senile infectious diseases with small sample size,low microbial abun-dance,difficult sampling or rapid bedside detection.In this paper,the latest research progress and application of CRISPR/Cas technology in the detection of pathogens of infectious diseases in the elderly were reviewed.
万方数据
维普
