Blood-brain barrier and Alzheimer's disease:dysfunctional illustration
The blood-brain barrier(BBB)is a critical structure for maintaining the homeostasis of the central nervous system.Its structural abnormalities and functional impairments allow harmful substances to infiltrate the brain,triggering neuroinflammation,β-amyloid(Aβ)deposition,tau protein hyperphosphorylation and other characteristic pathological changes of Alzheimer's disease(AD).The interaction of Aβ with microglia leads to the production of reactive oxygen species,which exacerbate oxidative stress and neuroinflammatory responses to further disrupt the integrity of the BBB.These findings not only deepen our understanding of the pathological mechanisms of AD but also offer new research directions for its diagnostic and therapeutic strategies.This paper reviews recent studies on the role and mechanism of BBB structural and functional disruptions in the pathogenesis of AD,discussing relevant molecular pathways,intercellular interactions,and their prospects in AD therapy.
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维普
