Protective effects of Bletilla striata polysaccharides on reproductive injury mice model
Objective To investigate the protective effect of Bletilla striata polysaccharides on the reproductive dysfunction of a mice model induced by ornidazole(ORN).Methods Male mice were randomly divided into six groups,each containing six mice:a blank control group,a reference capsule control group,a model control group,and three Bletilla striata polysaccharide dose groups(low,medium,and high).Except for the blank con-trol group,all other mice were administered ORN at a dose of 500 mg/kg orally for 21 days to establish a repro-ductive damage model.Then corresponding drugs were intragascasted for 30 days,and the weight change of mice was observed.The organ index,sperm survival rate of the testicles and epididymis,and oxidative damage in tes-ticular was determined,,and the pathological structure of mice testicles was observed.Results The testis and epididymis indices in the medium-dose group showed a significant increase compared to the model group(P＜0.05),the sperm motility in both the medium and high-dose groups was significantly improved(P＜0.05),and the superoxide dismutase(SOD)was significantly increased.The histological examination revealed a marked in-crease in the number of sperm-producing cells in the testis of mice treated with Bletilla striata polysaccharides at medium and high doses.Conclusion Bletilla striata polysaccharides improved the testis and epididymis indices,sperm count,and motility in mice with ORN-induced reproductive damage,indicating its potential therapeutic effect in mitigating oxidative stress-induced reproductive system impairment.
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维普
