Effect of roxadustat on renal anemia and lipid metabolism in non-dialysis patients with chronic kidney disease
Objective To evaluate the efficacy of roxadustat on renal anemia and lipid metabolism in non-dialy-sis patients with chronic kidney disease.Methods The clinical data of 89 patients with non-dialysis chronic kid-ney disease with renal anemia were analyzed retrospectively.All patients were divided into two groups:EPO group(n=46)and Roxadustat group(n=43)according to treatment.The levels of red blood cell,hemoglo-bin,serum iron,serum ferritin,total cholesterol and triglyceride before and after treatment were analyzed.Re-sults There was no statistical difference in baseline clinical data between the two groups except blood urea.The level of red blood cell and hemoglobin in the two groups were significantly higher than that before treatment(P＜0.05),but there was no statistically significant difference between the two groups after treatment(P＞0.05).The increase of hemoglobin in Roxadustat group was higher than that in EPO group(P＜0.05).Serum iron af-ter roxadustat treatment was higher than that before treatment(P＜0.05),but serum ferritin levels showed no sta-tistically significant difference(P＞0.05).After treatment,total cholesterol and triglyceride in Roxadustat group were lower than before treatment(P＜0.05).Conclusion Roxadustat can improve renal anaemia and the metab-olism of blood lipid in non-dialysis patients with chronic kidney disease.
万方数据
维普
