A case report of metaplastic breast cancer with intraductal papilloma in breast
Objective To investigate the imaging,immunohistochemical phenotype and differential diagnosis of metaplastic breast carcinoma with periaductal papilloma.Methods We retrospectively collected the pathological results and imaging data of a patient with metaplastic breast carcinoma with intraductal papilloma in our hospital,and reviewed relevant literature.Results The patient had a painless,tough mass in her right breast.Histomor-phology showed cystic tumor with a grayish-white bulge in the focal sac.Cells in the raised area were arranged in sheet and nest shape,with epithelial like and partially spindle shaped cells.The cells had obvious nuclear atyp-ia,and mitotic images and massive necrosis were easily visible.The cystic wall is fibrotic with bleeding,focal calcification and hemosiderin deposition.Some areas of the breast tissue surrounding the tumor showed fibroade-nomatous hyperplasia,and the focus showed intraductal papilloma.Conclusion The pathogenesis of metaplastic breast carcinoma with intraductal papilloma in breast is currently unclear,and its pathological manifestations are complex.The imaging findings do not have prominent features and are prone to misdiagnosis,making immuno-histochemistry helpful for differential diagnosis.In this case,the patient had biphasic metaplastic breast carcino-ma with positive Her-2 expression,with only sporadic reports found domestically and internationally.
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维普
