The application and mechanism progress of peripheral nerve repair materials based on tissue engineering method to promote nerve repair
Peripheral nerve injury is a common clinical disease,and it is still difficult to obtain the donor of nerve allograft in common repair methods.Nerve conduit is considered as a promising substitute for allogenic nerve in peripheral nerve repair,which can promote the regeneration and myelination of peripheral nerve fibers and repair damaged peripheral nerves.At present,peripheral nerve repair materials(PNRMs)are developing rapidly.This paper aimed at summarizing the research progress of PNRMs in promoting the regeneration and my-elination of peripheral nerve fibers,and focused on summarizing the design progress of materials and the mecha-nism that materials affect nerve cells through specific molecular mechanisms to repair peripheral nerves.By opti-mizing the design and application of materials,more kinds of nerve conduits will enter the clinic in the future,and a major breakthrough will be made in the treatment of peripheral nerve injury.
万方数据
维普
