Preparation and preliminary evaluation of sanggenon C inhalation powder aerosol
Objective To design and prepare sanggenon C inhalation powder aerosol,and evaluate its powder properties,inhalation performance and stability.Methods Poly(lactic-co-glycolic acid)was used as carrier ma-terial,dichloromethane and ethyl acetate were used as solvent,and polyvinyl alcohol was used as emulsifier.The sanggenon C loaded microspheres were prepared by emulsification-solvent evaporation method,and the powder was prepared by freeze drying method.The drug loading,encapsulation efficiency,powder properties,inhalation properties and stability of the powder were investigated.Results The prepared sanggenon C microspheres were spherical,the particle size of microspheres in the powder was (4.86±0.89 )μm,and the zeta potential was (-4.37±1.10)mV,which met the requirements of inhalation preparation.The moisture content was (3.01±0.59)％,and the weighting percentage of moisture absorption was (1.96±0.57)％. The bulk density was (0.136±0.005)g/ml,and the angle of repose was (24.31±2.54),thus the powder had good fluidity.It could be atomized quickly with good atomization performance,and the emptying rate was more than 90％ of the specified value.The encapsulation rate was about 100％,and the drug loading was (0.764±0.011 )％.The pH value was neutral,and it was stable at different temperatures.Conclusion The preparation of sanggenon C inhaled powder has reached the expected goal,which provides a certain experimental basis for the later biological application of this preparation.
万方数据
维普
