Pericoronary adipose tissue attenuation predicts major adverse cardiovascular events in patients with coronary heart disease
Objective To measure the average CT fat attenuation of pericoronary adipose tissue (PCAT)through coronary computed tomography angiography (CCTA)and to investigate its role in predicting major adverse events (MACE)in patients with coronary heart disease.Methods A total of 111 patients with coronary heart disease,with an average age of (58.56±9.87)years,who underwent CCTA,coronary angiography (CAG),and opti-cal coherence tomography (OCT)at our hospital from January 2022 to May 2023,were consecutively included. Based on the occurrence of MACE during the 1-year follow-up,patients were categorized into two groups:the MACE group and the no MACE group.MACE was defined as the composite endpoint of all-cause death,cardiac death,recurrent nonfatal myocardial infarction,ischemia-driven revascularization,recurrent angina,or heart failure.Cox regression analysis was employed to identify factors influencing clinical outcomes.Results After 1 year of follow-up,22 cases of MACE were recorded.Patients experiencing MACE exhibited higher levels of PCAT attenuation[-69.67 (-74.75,-65.59)vs-73.67 (-76.67,-69.50),P=0.037]compared to those without MACE.The Kaplan-Meier survival curve indicated that patients in the high PCAT attenuation group had a greater prevalence of MACE (log-rank 4.362,P=0.037).Cox proportional hazards regression a-nalysis revealed that both PCAT attenuation and severe vascular stenosis were associated with the incidence of MACE.Conclusion The findings of this study indicate that PCAT attenuation is significantly higher in the MACE group,suggesting that elevated PCAT attenuation may serve as a predictive marker for the occurrence of major cardiovascular adverse events in patients with coronary heart disease.
万方数据
维普
