Association between dietary fatty acid intake and breast cancer in adult women based on NHANES analysis
Objective To explore the relationship between saturated or unsaturated fatty acids and the incidence of breast cancer in adult women,so as to provide evidence for the prevention and management of breast cancer. Methods Cross sectional analysis was conducted based on the National Health and Nutrition Examination Survey (NHANES).Adult female participants in three cycles from 2013 to 2018 were included,and dietary data and breast cancer data were collected.Multivariate logistic regression was used to explore the effect of dietary saturat-ed fatty acids and unsaturated fatty acids on the incidence of breast cancer,and a restricted cubic spline (RCS) model was constructed to analyze the dose response relationship.Results A total of 1197 adult female partici-pants were included,and 63 of whom were found to have breast cancer (5 .26％).Compared with the control group,the intake of total saturated fatty acids,total monounsaturated fatty acids and total polyunsaturated fatty acids in breast cancer patients had no significant difference (P>0.05),while the intake of ω-3 andω-6 unsatu-rated fatty acids in the two groups had significant difference (P<0.05 ).Multivariate logistic regression results showed that after adjusting for age,race,smoking,hypertension and other covariates,the increased intake of ω-3 (OR=0.574)and ω-6 unsaturated fatty acids (OR=0.884)were independent risk factors for breast cancer in adult female patients (P<0.05 ).The RCS model showed that the intake of ω-3 and ω-6 unsaturated fatty acids had a negative nonlinear relationship with the incidence of breast cancer in adult women,and the trend was statistically significant (P<0.01).Conclusion The increased intake of ω-3 and ω-6 unsaturated fatty acids in adult women can reduce the risk of breast cancer,and a reasonable intake structure of fatty acids may help to re-duce the risk of breast cancer.
saturated fatty acidsunsaturated fatty acidsbreast cancernational health and nutrition examination surveycross sectional study
万方数据
维普
