摘要
目的:研究关苍术亲脂性成分的化学成分.方法:使用硅胶柱色谱、Sephadex LH-20柱色谱、中压液相色谱和半制备HPLC等方法对关苍术中的化学成分进行分离纯化,并通过理化性质和MS与NMR等波谱技术对其化学成分进行结构鉴定.结果:从关苍术药材中分离并鉴定了12种化合物,分别鉴定为osthol(1)、Atractylochromene(2)、6,7-二羟基-8-甲氧基香豆素(3)、8-羟基-6,7-二甲氧基香豆素(4)、7-甲氧基香豆素(5)、豆甾-4-烯-3-酮(6)、蒲公英萜醇乙酸酯(7)、白术内酯Ⅱ(8)、白术内酯Ⅰ(9)、桉叶-4(15)-烯-7β,11-二醇(10)、反式对羟基桂皮酸甲酯(11)、丁香醛(12).结论:化合物1,3～6,10～12为首次从关苍术中分离的化合物.
Abstract
Objective:To study the lipophilic chemical constituents of Atractylodes japonica.Methods:The chemical constituents of Atractylodes japonica were isolated and purified through the methods such as silica gel column chromatography,Sephadex LH-20 column chromatography,medium pressure liquid chromatography,and semi-preparative HPLC;and the structural identification of the components was conducted through physicochemical properties and MS and NMR spectroscopy techniques.Results:Twelve compounds were isolated and identified from Atractylodes japonica,which are osthol(1),atractylochromene(2),6,7-dihydroxy-8-methoxycoumarin(3),8-hydroxy-6,7-dimethoxycoumarin(4),7-methoxycoumarin(5),stigmast-4-en-3-one(6),taraxeryl acetate(7),atractylenolide Ⅱ(8),atractylenolide Ⅰ(9),eucalyptus-4(15)-ene-7β,11-diol(10),methyl 4-hydroxycinnamate(11),syringaldehyde(12).Conclusion:Compounds 1,3-6,10-12 are the first isolated compounds from Atractylodes japonica.
基金项目
黑龙江省自然科学基金项目(LH2019H048)
黑龙江省"头雁"团队支持项目(黑龙江省头雁行动领导小组文件[2019]5号)
黑龙江省博士后科研启动金资助项目(LBH-Q16207)
黑龙江省大学生创新创业训练计划项目(S202310228067)
黑龙江中医药大学新药研究基金(2018xy02)
国家科技期刊平台
NSTL
维普
万方数据