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王氏益经汤对多囊卵巢综合征患者游离睾酮指数的影响

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目的:探究王氏益经汤联合克罗米芬对多囊卵巢综合征(PCOS)患者月经情况、游离睾酮指数(FAI)及妊娠率的影响.方法:选择2021年1月—2022年1月烟台市中医医院收治的120例PCOS患者进行回顾性研究,依据随机数字表随机分为对照组60例和研究组60例,对照组采用克罗米芬治疗,研究组采用王氏益经汤联合克罗米芬治疗,两组均治疗3个月.比较两组患者的临床疗效、月经情况、总睾酮(T)、性激素结合球蛋白(SHGB)、FAI、妊娠率及不良反应发生率.结果:与对照组比较,研究组的总有效率(96.67%,58/60)显著高于对照组(83.33%,50/60)(P<0.05).治疗前,两组PCOS患者月经评分、T、SHBG及FAI水平比较,差异无统计学意义(P>0.05);治疗后,两组PCOS患者月经评分及T、FAI水平均显著降低(P<0.01,P<0.05),SHBG水平显著升高(P<0.05),且研究组优于对照组(P<0.01).与对照组比较,研究组的排卵率及妊娠率均明显增加(P<0.05),研究组不良反应的总发生率(5%,3/60)低于对照组(13.33%,8/60),但两组比较差异无统计学意义(P>0.05).结论:王氏益经汤联合克罗米芬治疗PCOS效果确切,可明显改善患者的月经情况及内分泌指标,显著提高患者的妊娠率.
Effects of Wang's Yijing Decoction on Free Androgen Index in Patients with Polycystic Ovary Syndrome
Objective:To investigate the effects of Wang's Yijing decoction combined with clomiphene on menstruation,free androgen index(FAI)and pregnancy rate in patients with polycystic ovary syndrome(PCOS).Methods:A retrospective study was conducted on 120 PCOS patients admitted to Yantai Traditional Chinese Medicine Hospital from January 2021 to January 2022.The patients were randomly divided into a control group(n = 60,treated with clomiphene)and a study group(n = 60,treated with Wang's Yijing decoction combined with clomiphene)using a random number table,and they were treated for 3 months.The clinical efficacy,menstruation,total testosterone(TT),sex hormone binding globulin(SHGB),FAI,pregnancy rate and adverse reaction rate of the two groups were compared.Results:Compared with the control group(96.67%,58/60),the total effective rate of the study group was obviously increased(83.33%,50/60;P<0.05).Before treatment,there was no obvious difference in menstrual scores,TT,SHBG and FAI in PCOS patients between the two groups(P>0.05);after treatment,the menstrual scores,TT and FAI of PCOS patients in both groups were obviously decreased(P<0.01 P<0.05),SHBG was obviously increased(P<0.05),and the degree of changes in the study group was more obvious(P<0.01).Compared with the control group(13.33%,8/60),the ovulation rate and pregnancy rate in the study group obviously increased(5%,3/60;P<0.05),the total incidence of adverse reactions in the study group was lower,while there was no obvious difference between the two groups(P>0.05).Conclusion:Wang's Yijing decoction combined with clomiphene has a definite therapeutic effect on PCOS,can obviously improve the menstruation and endocrine indicators of patients,and obviously increase the pregnancy rate.

Wang's Yijing decoctionClomiphenePolycystic ovary syndromeFree androgen indexPregnancy rate

黎田田、郑晶

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山东中医药大学,山东 济南 250355

烟台市中医医院,山东 烟台 264001

王氏益经汤 克罗米芬 多囊卵巢综合征 游离睾酮指数 妊娠率

国家自然科学基金项目山东省中医药科技发展计划项目

25660002-01712019-0675

2024

中医药信息
中华中医药学会,黑龙江中医药大学

中医药信息

影响因子:1.219
ISSN:1002-2406
年,卷(期):2024.41(1)
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