Objective:To compare the efficacy and toxicity of natural cinnabar and synthetic cinnabar.Methods:This paper adopted the suprathreshold hypnosis experiment model of chloral hydrate,and used the sleep latency and sleep duration of mice as indicators to investigate whether there is a difference in the hypnotic efficacy of the two types of cinnabar.The acute toxicity of two types of cinnabar in mice was observed after being gavaged at the maximum concentration and maximum volume of the drug(48 g/kg).The effects of two kinds of cinnabar on the toxicity of different organs were observed by using the body mass and organ index of mice as indexes and pathological sections of different organs.Results:The hypnotic experiment model of chloral hydrate showed that both natural and synthetic cinnabar(16.67 mg/kg,83.33 mg/kg)could prolong the sleep duration of mice induced by chloral hydrate,indicating that both natural and synthetic cinnabar had hypnotic effects.At a dose of 600 times the maximum dose(48 g/kg)of clinical medication administered by gavage,both types of cinnabar had no acute toxic effects on the mice,and there was no difference in mouse body weight,organ index,or toxicity to any organ compared to the blank group.Conclusion:The above research indicates that both natural cinnabar and synthetic cinnabar have hypnotic effects,and there is no significant difference in efficacy.Both types of cinnabar have no significant acute toxic effects.
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