Effect Study of Guanxin Decoction on Heart Rate Variability,Myocardial Microcirculation and Exercise Tolerance in Patients with Angina Pectoris of Qi Deficiency and Blood Stasis Type Based on the Theory of Collateral Disease
Objective:To investigate the effects of Guanxin Decoction on heart rate variability,myocardial microcirculation and exercise tolerance in patients with angina pectoris with qi deficiency and blood stasis based on collateral disease theory.Methods:A total of 112 patients with angina pectoris of qi deficiency and blood stasis type were selected.The subjects were randomly divided into control group and treatment group,with 56 patients in each group.The patients were respectively treated for 6 weeks with Western medicine or Guanxin Decoction combined with the same Western medicine.The indexes of heart rate variability,high-frequency(HF)power,standard deviation of normal sinus boreal interval(SDNN),difference of adjacent sinus boreal interval>50 ms percentage of boreal number(PNN50),square root of difference of normal adjacent sinus boreal interval(RMSSD),exercise tolerance indicators 6-minute walking test(6MWT),as well as traditional Chinese medicine syndrome scores were compared between the two groups before and after treatment.After treatment,the myocardial microcirculation indexes of the two groups were compared,including the proportion of left circumflex artery corrected time flow frame count(LCX CTFC),right coronary artery corrected time flow frame count(RCA CTFC),left anterior descending artery corrected time flow frame count(LAD CTFC),and TIMI myocardial tissue perfusion grade(TMPG)reaching grade 3 standard.The clinical efficacy and the occurrence of adverse reactions were also compared between the two groups.Results:After treatment,the levels of heart rate variability indicators HF,SDNN,PNN50 and RMSSD in the two groups were higher than those before treatment(P<0.05),and these levels in the study group were higher than those in the control group(P<0.05).After treatment,the level of 6MWT in the two groups was higher than that before treatment(P<0.05),and the level of TCM syndrome score was lower than that before treatment(P<0.05).The level of 6MWT in the study group was higher than that in the control group(P<0.05),and the level of TCM syndrome score was lower than that in the control group(P<0.05).After treatment,the levels of LCX CTFC,RCA CTFC and LAD CTFC in the study group were lower than those in the control group(P<0.05),and the proportion of TMPG grade 3 was higher than that in the control group(P<0.05).The clinical efficacy of the study group was higher than that of the control group(P<0.05)and there was no difference in the incidence of adverse reactions between the two groups(χ2 = 0.121,P = 0.728).Conclusion:Based on the collateral disease theory,Guanxin decoction is effective in treating angina pectoris of qi deficiency and blood stasis type,and can better alleviate the clinical symptoms of the patients,improve the heart rate variability,exercise tolerance and myocardial microcirculation,and has high safety.
万方数据
维普
