摘要
钩藤始载于《名医别录》,应用历史悠久.本文查阅钩藤化学成分和药理作用的相关研究文献,发现钩藤主要含有生物碱类、三萜类、酚类、甾醇类、黄酮类、醌类、香豆素类和木脂素类等成分,具有降压、抗氧化应激、抗神经细胞凋亡、调节炎症因子及其相关通路、降脂、抗脑缺血再灌注损伤、抗纤维化、抗抑郁、抗癌和调整肠道菌群等作用,主要作用于心血管和中枢神经系统,通过调节RhoA/ROCK1、ERK/MAPK、p38MAPK/MAPK、JNK/MAPK、Akt/eNOS、PI3K/Akt、ERK1/2、p27Kip1、PI3K/Akt/GSK-3β、Src/STAT3和HIF-1α/EMT信号通路,发挥治疗高血压、阿尔茨海默病、帕金森、肺纤维化等疾病的作用.
Abstract
Gambir plant nod was first recorded in the Records of Famous Doctors and has a long history of application.This article reviews relevant research literature on the chemical components and pharmacological effects of Uncaria lobata,and finds that Uncaria lobata mainly contains alkaloids,triterpenes,phenols,sterols,flavonoids,quinones,coumarins,and lignans.It has antihypertensive,antioxidant stress,anti neuronal apoptosis,regulation of inflammatory factors and related pathways,lipid-lowering,anti cerebral ischemia-reperfusion injury,anti fibrosis,anti depression,anti-cancer,and adjustment of gut microbiota effects.They mainly act on the cardiovascular and central nervous systems,regulating RhoA/ROCK1,ERK/MAPK,p38MAPK/MAPK,JNK/MAPK,Akt/eNOS,PI3K/Akt,ERK1/2,p27Kip1,PI3K/Akt/GSK-3β,Src/STAT3 and HIF-1α/The EMT signaling pathway,and play a role in treating diseases such as hypertension,Alzheimer′s disease,Parkinson′s disease,and pulmonary fibrosis.
基金项目
第七批全国老中医药专家学术经验继承项目(国中医药办人教函[2022]76号)
维普
万方数据