Research Progress on the Chemical Components and Pharmacological Effects of Gambir Plant Nod
Gambir plant nod was first recorded in the Records of Famous Doctors and has a long history of application.This article reviews relevant research literature on the chemical components and pharmacological effects of Uncaria lobata,and finds that Uncaria lobata mainly contains alkaloids,triterpenes,phenols,sterols,flavonoids,quinones,coumarins,and lignans.It has antihypertensive,antioxidant stress,anti neuronal apoptosis,regulation of inflammatory factors and related pathways,lipid-lowering,anti cerebral ischemia-reperfusion injury,anti fibrosis,anti depression,anti-cancer,and adjustment of gut microbiota effects.They mainly act on the cardiovascular and central nervous systems,regulating RhoA/ROCK1,ERK/MAPK,p38MAPK/MAPK,JNK/MAPK,Akt/eNOS,PI3K/Akt,ERK1/2,p27Kip1,PI3K/Akt/GSK-3β,Src/STAT3 and HIF-1α/The EMT signaling pathway,and play a role in treating diseases such as hypertension,Alzheimer′s disease,Parkinson′s disease,and pulmonary fibrosis.
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维普
