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牛膝盐炙工艺研究

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目的:探究牛膝最佳盐炙工艺.方法:采用超高效液相色谱串联质谱技术,以牛膝补肾壮骨的5种有效成分——β-蜕皮甾酮、25R-牛膝甾酮、25S-牛膝甾酮、人参皂苷R0及竹节参皂苷Ⅳa为评价指标,采用单因素和Box-Behnken设计方法,选择加盐量、炒制温度和炒制时间为考察因素,优化牛膝的盐炙工艺.结果:牛膝盐炙最佳工艺为2%加盐量,炒制温度100℃,炒制时间20 min.结论:所得牛膝盐炙工艺稳定可靠,有利于提高牛膝盐炙品的质量均一性.
Stir-Baking with Salt Technique of Achyranthis Bidentatae Radix
Objective:To explore the best stir-baking with salt of Achyranthis Bidentatae Radix.Methods:In order to optimize stir-baking with salt of Achyranthis Bidentatae Radix,the technique of ultra high performance liquid chromatography tandem mass spectrometry was adopted;five effective ingredients for tonifying kidney and strengthening bone of Achyranthis Bidentatae Radix,β-Ecdysterone,25R Achyranthes,25S Achyranthes,Ginsenoside R0,and Bamboo Joint Ginsenoside Iva,were taken as evaluation indicators;single factor and Box Behnken design methods was employed;and the amount of salt added,frying temperature,and frying time were the factors to be investigated.Results:The best technique of stir-baking with salt of Achyranthis Bidentatae Radix was that the amount of salt is 2%,stirring temperature 100℃,stirring time 20 min.Conclusion:The ingredients of stir-baking with salt of Achyranthis Bidentatae Radix are stable and reliable,which is beneficial to the quality uniformity of Achyranthis Bidentatae Radix processed with salt.

Achyranthis Bidentatae RadixBox-Behnken design-response surface methodologyStir-baking with saltEffective componentsUltra high performance liquid chromatography tandem mass spectrometry

张世豪、那叶馨、东娇娇、胡建华、薛金浩、高诗雯、杨柳

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黑龙江中医药大学,北药基础与应用研究省部共建教育部重点实验室,黑龙江省中药及天然药物药效物质基础研究重点实验室,黑龙江 哈尔滨 150040

牛膝 Box-Behnken响应面法 盐炙 有效成分 超高效液相色谱串联质谱

国家自然科学基金黑龙江省自然科学基金国家自然科学基金配套项目黑龙江省青年岐黄学者培养项目黑龙江省头雁创新团队计划全国名老中医药专家传承工作室建设项目全国老中医药专家学术经验继承项目(第七批)黑龙江中医药大学研究生创新基金

81803690LH2021H0972018PT02[2022]75[2022]762023yjscx034

2024

10.19656/j.cnki.1002-2406.20240302

中医药信息
中华中医药学会,黑龙江中医药大学

中医药信息

影响因子：1.219
ISSN：1002-2406
年,卷(期)：2024.41(3)
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