Clinical Study on Tongmai Fuzhi Formula in the Treatment of Vascular Cognitive Impairment with No Dementia in First Episode Cerebral Infarction Patients
Objective:To evaluate the effect of Tongmai Fuzhi formula(TFF)on early intervention of vascular cognitive impairment with no dementia(VCIND)in first episode ischemic stroke.Methods:Sixty-eight patients with first episode cerebral infarction VCIND who met the inclusion criteria were randomly divided into treatment group and control group by envelope method,with 34 patients in each group.Both groups were given routine treatment.The treatment group was added with TFF granule orally,while the control group was added with oral placebo,and both groups were treated for 30 days.The latent period and amplitude of P300 potential,MoCA scale,MMSE scale and TCM syndrome score were compared between the two groups before and after treatment.Results:After treatment,MoCA scale,MMSE scale and P300 amplitude increased in both groups(P<0.05),TCM syndrome score and P300 latency decreased(P<0.05),and the above indexes in the treatment group were significantly better than those in the control group(P<0.05).The effective rate of TCM syndrome in the treatment group was 88.24%(30/34),which was better than that in the control group(52.94%(18/34),and the difference was statistically significant(P<0.05).The effective rate of MoCA scale score in the treatment group was 88.24%(30/34),which was better than that in the control group(50%(17/34),and the difference was statistically significant(P<0.05).Conclusion:Tongmai Fuzhi formula can significantly improve VCIND in first episode ischemic stroke.
Ischemic strokeVascular cognitive impairment with no dementiaP300
万方数据
维普
