Research Progress of Traditional Chinese Medicine Prevention and Treatment of Inflammatory Bowel Disease Based on Mitochondrial Dysfunction
Inflammatory bowel disease(IBD)is a group of global diseases characterized by chronic intestinal inflammation,including Crohn's disease(CD)and ulcerative colitis(UC),and its etiology and pathogenesis are still not fully clear.Mitochondria are important organelles in cells.Studies have found that the decrease of mitochondrial membrane potential,the decrease of adenine nucleoside triphosphate(ATP)production,and the intensification of oxidative stress may promote the abnormal activation of the immune system,cause damage to the intestinal mucosal barrier,lead to the occurrence of IBD,and accelerate the progression of inflammation.Traditional Chinese medicine contains a variety of bioactive ingredients,which have the potential to repair mitochondrial function and inhibit inflammatory reactions.This article summarizes and sorts out the prevention and treatment of inflammatory bowel disease using traditional Chinese medicine based on mitochondrial function.It is found that traditional Chinese medicine has the functions of alleviating oxidative stress and regulating autophagy on mitochondria,thereby exerting anti-inflammatory,antioxidant,reducing intestinal mucosal damage,and delaying disease progression.In addition,the mechanism of inflammation-cancer transformation involved in the regulation of mitochondrial DNA(mt DNA)mutation by traditional Chinese medicine is a current research focus.
万方数据
维普
