The Mechanism and Clinical Research Progress of Acupuncture Treatment for Mild Cognitive Impairment
Mild cognitive impairment(MCI)is a transitional stage between normal aging and age-related AD.According to statistics,10%to 15%of MCI patients will change to AD,and the conversion rate is 10 times that of normal aging.Acupuncture,as an important part of traditional Chinese medicine,has been widely used in the treatment of MCI because of its efficacy and safety,which has been verified by a large number of domestic clinical trials.It has the characteristics of multi-target,multi-pathway and multifaceted action,and is safe and effective.The author summarized the mechanism of acupuncture treatment of MCI and related clinical research literature,and found that acupuncture can inhibit Aβ deposition,Tau protein hyperphosphorylation,inflammatory response,oxidative stress,and regulate the cholinergic system.In clinical treatment,the combination of acupuncture and medicine in the treatment of MCI has a better effect and a good synergistic effect.