Clinical Study on the Treatment of Sepsis Complicated with Acute Gastrointestinal Injury by Modified Yellow Dragon Decoction Combined with Moxibustion
Objective:To investigate the clinical efficacy of Modified Yellow Dragon Decoction(MYDD)combined with moxibustion in the treatment of sepsis complicated with acute gastrointestinal injury(AGI).Methods:Sixty patients with sepsis complicated with AGI who met the inclusion criteria were randomly divided into a control group and a study group,with 30 cases in each group.The control group received conventional Western medicine treatment,while the study group received MYDD combined with moxibustion in addition to the treatment for the control group,with a total treatment duration of 7 days.The changes in gastric mucosal secretion function(gastric pepsinogen Ⅰ and Ⅱ),gastrointestinal function-related indicators(intestinal peristalsis,intra-abdominal pressure,gastrointestinal dysfunction score),traditional Chinese medicine syndrome score,Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score,and Sequential Organ Failure Assessment(SOFA)score were compared between the two groups before and after treatment.Clinical efficacy,ICU hospitalization time,incidence of multiple organ dysfunction syndrome(MODS),and 28-day mortality were also compared.Results:Compared with before treatment,the levels of gastric pepsinogen Ⅰ and Ⅱ(PG Ⅰ,PG Ⅱ)increased in both groups after treatment(P<0.05),and the levels of PG Ⅰ and PG Ⅱ in the study group were higher than those in the control group after treatment(P<0.01).After treatment,intestinal peristalsis increased(P<0.05),intra-abdominal pressure and gastrointestinal dysfunction score decreased(P<0.05)in both groups.Additionally,the study group had higher intestinal peristalsis(P<0.01)and lower intra-abdominal pressure and gastrointestinal dysfunction score(P<0.05,P<0.01)compared with the control group after treatment.After treatment,traditional Chinese medicine syndrome score,APACHE Ⅱ score,and SOFA score decreased in both groups(P<0.05),and the study group had lower traditional Chinese medicine syndrome score,APACHE Ⅱ score,and SOFA score than the control group(P<0.01).The total effective rate in the study group(96.67%,29/30)was higher than that in the control group(76.67%,23/30)after treatment(P<0.05).The study group had a shorter ICU hospitalization time(P<0.01),lower incidence of MODS(16.67%,5/30)compared with the control group(40%,12/30)(P<0.05),and lower 28-day mortality rate(13.33%,4/30)compared with the control group(36.67%,11/30)(P<0.05).Conclusion:Modified Yellow Dragon Decoction combined with moxibustion can improve gastric mucosal secretion function,gastrointestinal function,reduce clinical scores,improve comprehensive efficacy,shorten ICU hospitalization time,and reduce the incidence of MODS and 28-day mortality in patients with sepsis complicated with AGI.
SepsisAcute Gastrointestinal InjuryModified Yellow Dragon DecoctionMoxibustionGastrointestinal Function
国家科技期刊平台
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