Research Progress on Pharmacological Effects of Siwu Decoction
Siwu Decoction is a basic formula for nourishing and regulating blood,with the characteristics of nourishing blood without stagnation and moving blood without damaging it.It is used to treat various clinical diseases and has high clinical value.The authors found through reviewing relevant research literature that this formula has pharmacological effects such as supplementing blood volume,promoting blood circulation and anticoagulation,estrogen like effects,bidirectional regulation of the uterus,improving ovarian function,lowering blood lipids,enhancing learning and memory ability,antioxidant damage,anti-inflammatory and antibacterial,enhancing immune function,anti-aging,liver protection and radiation resistance,drug damage and anti-mutation.It mainly acts on the blood system,female reproductive system,and cardiovascular and cerebrovascular systems.The therapeutic effects are mainly achieved through phosphatidylinositol-3-kinase/protein kinase B(PI3K/Akt)signaling pathway,epidermal growth factor receptor/phosphatidylinositol-3-kinase(EGFR/PI3K)signaling pathway,liver kinase B1/adenylate activated protein kinase(LKB1/AMPK)signaling pathway,etc.
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