基于"肾主骨"理论探讨肠道微生态与骨质疏松症的相关性
Exploring the Relationship between Gut Microbiota and Osteoporosis Based on the Theory of"Kidney Governing Bones"
杨青峰 1张翔 1刘耀忠 1刘佳瑞 1吕文飞 1赵川槐 1王晓宇 1蒋宜伟2
作者信息
- 1. 北京中医医院内蒙古医院,内蒙古自治区 巴彦淖尔 015000
- 2. 甘肃中医药大学,甘肃 兰州 730000
- 折叠
摘要
随着分子生物学的迅速发展,肠道微生态与骨质疏松症(OP)的关系研究成为临床研究的热点.中医学在脏腑论治OP方面仅有中医理论的支撑,尚未得到足够的现代医学验证.因此,本文以"肾主骨"理论为出发点,以肠道微生态为切入点,对肾虚与OP发病关系进行论述,发现OP患者容易引发肠道微生态失调,而肠道微生态紊乱会通过神经炎症、短链脂肪酸和肠道屏障等途径加速OP的进程.
Abstract
With the rapid development of molecular biology,the relationship between gut microbiota and osteoporosis(OP)has become a hot topic in clinical research.Traditional Chinese medicine(TCM)has theoretical support in the treatment of OP based on the theory of"kidney governing bones",but it has not yet received sufficient validation from modern medicine.Therefore,starting from the theory of"kidney governing bones"and focusing on gut microbiota,this paper discusses the relationship between kidney deficiency and OP.It is found that OP patients are prone to gut microbiota imbalance,and disturbances in gut microbiota can accelerate the progression of OP through pathways such as neuroinflammation,short-chain fatty acids,and intestinal barrier disruption.
关键词
肾主骨/肠道微生态/骨质疏松症Key words
Kidney governing bones/gut microbiota/osteoporosis引用本文复制引用
基金项目
国家自然科学基金项目(82160916)
内蒙古自治区重点研发和成果转化项目(2023YFSH0049)
出版年
2024
国家科技期刊平台
NSTL
万方数据